The NLRP3 inflammasome, a target for therapy in diverse disease states
- 3 March 2010
- journal article
- review article
- Published by Wiley in European Journal of Immunology
- Vol. 40 (3), 631-634
- https://doi.org/10.1002/eji.200940162
Abstract
A role for NLRP3 inflammasome in recurrent and chronic inflammation was initially described in a group of rare autoinflammatory conditions, termed cryopyrin‐associated periodic syndrome. Subsequently, inflammasomes have been implicated in the pathology of many common diseases, including cancer, gout and diabetes. Despite diverse pathologies, the central role of the inflammasome in innate defences and tumour elimination suggests common therapeutic approaches to reduce inflammation where appropriate.Keywords
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