Coat Variation in the Domestic Dog Is Governed by Variants in Three Genes
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- 2 October 2009
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 326 (5949), 150-153
- https://doi.org/10.1126/science.1177808
Abstract
Dog Coats Shed Genetic Secrets: The coats of domestic dogs show great variation—long, short, straight, wavy, curly, wiry, or smooth. To investigate how this variation arises, Cadieu et al. (p. 150 , published online 27 August) performed genome-wide association studies on 80 different dog breeds. The coat phenotype could be dissected into three simple traits of length, curl, and growth pattern or texture with each trait controlled by one major gene, FGF5 (fibroblast growth factor-5), KRT71 (keratin-71), and RSPO2 (R-spondin-2), respectively. In combination, variants in these three genes alone account for the vast majority of the coat phenotypes in purebred dogs in the United States. Thus, a small number of simply inherited traits can be remixed to create extraordinary phenotypic variation.Keywords
This publication has 23 references indexed in Scilit:
- Role of 5′‐ and 3′‐untranslated regions of mRNAs in human diseasesBiology of the Cell, 2009
- Enhanced ectodysplasin-A receptor (EDAR) signaling alters multiple fiber characteristics to produce the East Asian hair formHuman Mutation, 2008
- A Mutation in Hairless Dogs Implicates FOXI3 in Ectodermal DevelopmentScience, 2008
- Efficient mapping of mendelian traits in dogs through genome-wide associationNature Genetics, 2007
- Mutations within the FGF5 gene are associated with hair length in catsAnimal Genetics, 2007
- A Single IGF1 Allele Is a Major Determinant of Small Size in DogsScience, 2007
- The long and the short of it: evidence that FGF5 is a major determinant of canine ‘hair’‐itabilityAnimal Genetics, 2006
- Genome sequence, comparative analysis and haplotype structure of the domestic dogNature, 2005
- Coiled coils meet the chaperone worldTrends in Biochemical Sciences, 2004
- Genetic Dissection of Complex TraitsScience, 1994