Bioactive Kaurane Diterpenoids from Annona glabra
- 1 April 1998
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 61 (4), 437-439
- https://doi.org/10.1021/np970497z
Abstract
Phytochemical analysis of the fruits of Annona glabra yielded two new kaurane diterpenoids, annoglabasin A (methyl-16 beta-acetoxy-19-al-ent-kauran-17-oate)(1) and annoglabasin B (16 alpha-hydro-19-acetoxy-ent-kauran-17-oic acid)(2), along with 11 known kaurane derivatives (3-13). The structures of the new compounds were established by spectral and chemical evidence. Among these, methyl-16 alpha-hydro-19-al-ent-kauran-17-oate (11) exhibited mild activity against HIV replication in H9 lymphocyte cells, and 16 alpha-17-dihydroxy-ent-kauran-19-oic acid (4) showed significant inhibition of HIV-reverse transcriptase.Keywords
This publication has 2 references indexed in Scilit:
- Diterpenes from Euphorbia neriifoliaPhytochemistry, 1990
- Antitumour and antibiotic principles of Annona senegalensisPhytochemistry, 1976