Near-infrared imaging in the small animal brain: optimization of fiber positions
- 1 January 2003
- journal article
- Published by SPIE-Intl Soc Optical Eng in Journal of Biomedical Optics
- Vol. 8 (1), 102-110
- https://doi.org/10.1117/1.1528597
Abstract
We investigate fiber placement issues associated with a hybrid magnetic resonance imaging (MRI) near-infrared (NIR) imaging technique for small animal brain studies. Location of the optical fibers on the cranium is examined, with an emphasis on maximizing the recovered resolution and contrast in the region of interest, which in this case is the murine brain. In a series of simulation studies, singular value decomposition of the Jacobian is used in order to determine the measurement sites that provide the most information about the region of interest. The modeling results indicate that data collected using fibers arranged on one side of the head near the brain contain as much information about optical changes within the brain as those positioned equally spaced around the entire periphery of the head. Practical space limitation considerations favor the one-sided fiber array geometry in the case where the NIR acquisition is expected to occur simultaneously with MRI. © 2003 Society of Photo-Optical Instrumentation Engineers.Keywords
This publication has 20 references indexed in Scilit:
- Quantitative Hemoglobin Tomography with Diffuse Near-Infrared Spectroscopy: Pilot Results in the BreastRadiology, 2001
- Near-infrared diffuse tomography combined with a priori MRI structural information: testing a hybrid image reconstruction methodology with functional imaging of the rat craniumProceedings of SPIE, 1999
- Optical tomography in medical imagingInverse Problems, 1999
- Bold MRI vs. NIR SpectrophotometryPublished by Springer Science and Business Media LLC ,1998
- Non-invasive optical spectroscopy and imaging of human brain functionTrends in Neurosciences, 1997
- Optical investigations of physiology. A study of intrinsic and extrinsic biomedical contrastPhilosophical Transactions Of The Royal Society B-Biological Sciences, 1997
- Quantification in tissue near–infrared spectroscopyPhilosophical Transactions Of The Royal Society B-Biological Sciences, 1997
- Simultaneous Recording of Cerebral Blood Oxygenation Changes during Human Brain Activation by Magnetic Resonance Imaging and Near-Infrared SpectroscopyJournal of Cerebral Blood Flow & Metabolism, 1996
- Optical image reconstruction using frequency-domain data: simulations and experimentsJournal of the Optical Society of America A, 1996
- Reconstruction methods for infrared absorption imagingPublished by SPIE-Intl Soc Optical Eng ,1991