Evaluation of Carotid-Femoral Pulse Wave Velocity
Open Access
- 1 February 2005
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Hypertension
- Vol. 45 (2), 222-226
- https://doi.org/10.1161/01.hyp.0000154229.97341.d2
Abstract
Carotid-femoral pulse wave velocity (PWV), a measure of arterial stiffness, is determined from the time taken for the arterial pulse to propagate from the carotid to the femoral artery. Propagation time is measured variously from the foot of the waveform or point of maximum upslope. We investigated whether these methods give comparable values of PWV at rest, during β-adrenergic stimulation, and pacing-induced tachycardia. In subjects at rest (n=43), values obtained using the foot-to-foot method (SphygmoCor system) were 1.7±0.75 m/s (mean±SD) greater than those obtained using the maximum slope (Complior system) at a mean value of 12 m/s. Isoprotenerol (0.5 to 1.5 μg/min; n=10), and pacing (in subjects with permanent pacemakers; n=11) increased heart rate but had differential effects on systolic blood pressure and pulse pressure. The increase in heart rate produced by isoprotenerol (18±3 bpm) and pacing (40 bpm) was associated with an increase in PWV measured using both systems (increases of 0.7±0.2 m/s and 0.9±0.2 m/s for SphygmoCor and Complior, respectively, during isoprotenerol and increases of 2.1±0.5 m/s and 1.1±0.2 m/s for SphygmoCor and Complior, respectively, during pacing, each P <0.001). Reanalysis of waveforms recorded from the Complior system using the foot-to-foot method produced similar values of PWV to those obtained with the SphygmoCor, confirming that the difference between these systems was attributable to the timing algorithm rather than other aspects of signal acquisition. Carotid-femoral PWV is critically dependent on the method used to determine propagation time, but this does not account for variation of PWV with heart rate.Keywords
This publication has 16 references indexed in Scilit:
- Confounding effects of heart rate on pulse wave velocity in paced patients with a low degree of atherosclerosis.Journal of Hypertension, 2004
- Effects of Inhibition of Basal Nitric Oxide Synthesis on Carotid-Femoral Pulse Wave Velocity and Augmentation Index in HumansHypertension, 2003
- Aortic Stiffness Is an Independent Predictor of Fatal Stroke in Essential HypertensionStroke, 2003
- Arterial stiffness, gender and heart rateJournal of Hypertension, 2003
- Influence of sex on the relation between heart rate and aortic stiffnessJournal of Hypertension, 2003
- Aortic Pulse-Wave Velocity and Its Relationship to Mortality in Diabetes and Glucose IntoleranceCirculation, 2002
- Heart RateHypertension, 2002
- Determination of pulse wave velocities with computerized algorithmsAmerican Heart Journal, 1991
- The relationship between arterial pulse-wave velocity and pulse frequency at different pressuresJournal of Medical Engineering & Technology, 1984
- The dynamic elastic properties of the arterial wallJournal Of Physiology-London, 1961