Unexpected contribution of cytochrome P450 enzymes CYP11B2 and CYP21, as well as CYP3A4 in xenobiotic androgen elimination – Insights from metandienone metabolism
- 18 September 2012
- journal article
- Published by Elsevier BV in Toxicology Letters
- Vol. 213 (3), 381-391
- https://doi.org/10.1016/j.toxlet.2012.07.020
Abstract
No abstract availableKeywords
Funding Information
- The Manfred Donike Institut für Doping Analytik e.V., Cologne
- Federal Ministry for the Interior, Berlin
This publication has 30 references indexed in Scilit:
- The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its DisordersEndocrine Reviews, 2011
- Approaches to deorphanization of human and microbial cytochrome P450 enzymesBiochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2011
- CYP21-catalyzed production of the long-term urinary metandienone metabolite 17β-hydroxymethyl-17α-methyl-18-norandrosta-1,4,13-trien-3-one: a contribution to the fight against dopingBiological Chemistry, 2009
- The genome sequence of Schizosaccharomyces pombeNature, 2002
- Metabolism of anabolic steroids in man: synthesis and use of reference substances for identification of anabolic steroid metabolitesAnalytica Chimica Acta, 1993
- Metabolism of metandienone in man: Identification and synthesis of conjugated excreted urinary metabolites, determination of excretion rates and gas chromatographic-mass spectrometric identification of bis-hydroxylated metabolitesThe Journal of Steroid Biochemistry and Molecular Biology, 1991
- Expression and Functional Study of Wild-Type and Mutant Human Cytochrome P450c21 inSaccharomyces cerevisiaeDNA and Cell Biology, 1991
- Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronismBiochemical and Biophysical Research Communications, 1990
- Cloning of cDNA and genomic DNA for human cytochrome P‐45011βFEBS Letters, 1990
- Metabolism of stanozolol: Identification and synthesis of urinary metabolitesJournal of Steroid Biochemistry, 1990