The role of prophylactic anticonvulsants in moderate to severe head injury
Open Access
- 22 July 2010
- journal article
- review article
- Published by Springer Science and Business Media LLC in International Journal of Emergency Medicine
- Vol. 3 (3), 187-191
- https://doi.org/10.1007/s12245-010-0180-1
Abstract
Post-traumatic seizures cause secondary brain injury, contributing to morbidity and mortality after traumatic brain injury. Seizure activity may be undetectable if the patient is paralysed and ventilated. The effect of prophylactic anticonvulsant therapy on the prevention of seizures after moderate to severe traumatic brain injury was studied. A structured systematic literature review was performed. There may be a place for prophylactic anticonvulsants in the prophylaxis of early post-traumatic seizures. Further randomised controlled trials are needed to firmly establish the benefits of prophylactic anticonvulsants.Keywords
This publication has 11 references indexed in Scilit:
- XIII. Antiseizure ProphylaxisJournal of Neurotrauma, 2007
- Post-traumatic seizure disorder following acquired brain injuryBrain Injury, 2007
- Prophylaxis of the epilepsies: should anti-epileptic drugs be used for preventing seizures after acute brain injury?2005
- A randomized, double-blinded, placebo-controlled trial of phenytoin for the prevention of early posttraumatic seizures in children with moderate to severe blunt head injuryAnnals of Emergency Medicine, 2004
- Overview of Studies to Prevent Posttraumatic EpilepsyEpilepsia, 2003
- Antiepileptogenesis and Seizure Prevention Trials with Antiepileptic Drugs: Meta‐Analysis of Controlled TrialsEpilepsia, 2001
- Increased incidence and impact of nonconvulsive and convulsive seizures after traumatic brain injury as detected by continuous electroencephalographic monitoringJournal of Neurosurgery, 1999
- Practice parameter: Antiepileptic drug treatment of posttraumatic seizuresArchives of Physical Medicine and Rehabilitation, 1998
- Practice parameter: antiepileptic drug treatment of posttraumatic seizures. Brain Injury Special Interest Group of the American Academy of Physical Medicine and Rehabilitation.1998
- A Randomized, Double-Blind Study of Phenytoin for the Prevention of Post-Traumatic SeizuresNew England Journal of Medicine, 1990