Median and Ulnar Neuropathy Assessment in Parkinson’s Disease regarding Symptom Severity and Asymmetry
Open Access
- 24 October 2016
- journal article
- research article
- Published by Hindawi Limited in Parkinson's Disease
- Vol. 2016, 1-7
- https://doi.org/10.1155/2016/4958068
Abstract
Background. While increasing evidence suggests comorbidity of peripheral neuropathy (PNP) and Parkinson’s disease (PD), the pathogenesis of PNP in PD is still a debate. The aim of this article is to search the core PD symptoms such as rigidity and tremor as contributing factors to mononeuropathy development while emphasizing each individual patient’s asymmetric symptom severity.Methods. We studied 62 wrists and 62 elbows of 31 patients (mean age) and 64 wrists and 64 elbows of 32 age-gender matched healthy controls (mean age,). The Hoehn and Yahr disability scale and Unified Parkinson’s Disease Rated Scale were used to determine the severity of the disease.Results. According to electrodiagnostic criteria, we confirmed median neuropathy in 16.12% (bilateral in two-thirds of the patients) and ulnar neuropathy in 3.22% of the PD group. While mean age (), age at PD onset (), and H&Y scores () were significant, tremor and rigidity scores were not. The comparison of the mean indices of electrophysiologic parameters indicated subclinical median and ulnar nerve demyelination both at the wrist and at the elbow in the patient groups where a longer disease duration and mild tremor and rigidity scores are prominent, remarkably.Conclusion. A disease related peripheral neurodegeneration beyond symptom severity occurs in PD.
Keywords
This publication has 22 references indexed in Scilit:
- Associations between work-related factors and specific disorders at the elbow: a systematic literature reviewRheumatology, 2008
- Consensus Statement of the Movement Disorder Society on TremorMovement Disorders, 2008
- The role of spectroscopy in parkinsonismMovement Disorders, 1998
- Tremor associated with benign IgM paraproteinaemic neuropathyBrain, 1996
- The natural history of chronic demyelinating neuropathy associated with benign IgM paraproteinaemiaBrain, 1994
- Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.Journal of Neurology, Neurosurgery & Psychiatry, 1992
- Frozen shoulder and other shoulder disturbances in Parkinson's disease.Journal of Neurology, Neurosurgery & Psychiatry, 1989
- Pressures recorded in ulnar neuropathyActa Orthopaedica, 1985
- ParkinsonismNeurology, 1967
- Deformities of the hands and feet in Parkinsonism and their reversibility by operationJournal of Neurology, Neurosurgery & Psychiatry, 1963