The effects of ketorolac and morphine on articular cartilage and synovium in the rabbit knee joint
- 1 July 2004
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 82 (7), 502-505
- https://doi.org/10.1139/y04-066
Abstract
Analgesics are commonly injected intra-articularly for analgesia after arthroscopic surgery, especially of knee joints. The aim of this study was to research the effects of ketorolac and morphine on articular cartilage and synovial membrane. This study used rabbit right and left hind knee joints. The treatments, saline, morphine, or ketorolac, were administered intra-articularly 24 h after injection, and 5 joints from animals in each drug group were chosen randomly to form Group I and subgroups of Group I. The same procedures were applied after 48 h and 10 days of injection to form Groups II and III, respectively, and subgroups of these groups. Knee joints were excised and a blinded observer evaluated the histopathology according to inflammation of the articular cartilage, inflammatory cell infiltration, hypertrophy, and hyperplasia of the synovial membrane. No histopathological changes were found in the control groups. In the ketorolac and morphine groups, there were varying degrees of synovial membrane inflammatory cell infiltration and minimal, mild, or moderate synovial membrane cell hyperplasia or hypertrophy. Except for the ketorolac group at 24 h, both ketorolac and morphine groups showed more histopathological changes than controls (p < 0.05). Morphine and ketorolac both cause mild histopathological changes in rabbit knee joints, morphine causing more than ketorolac, but both of the drugs can be used intra-articularly with safety.Key words: intra-articular analgesia, knee joint, histopathological changes, articular cartilage, synovial membrane.Keywords
This publication has 16 references indexed in Scilit:
- Analgesic Effects of Intraarticular Sufentanil and Sufentanil Plus Methylprednisolone After Arthroscopic Knee SurgeryAnesthesia & Analgesia, 2004
- The effects of morphine on human articular cartilage of the kneeArthroscopy: The Journal of Arthroscopic & Related Surgery, 2002
- Intraarticular glucocorticoid, morphine and bupivacaine reduces pain and convalescence after arthroscopic ankle surgery: A randomized study of 36 patientsActa Orthopaedica, 2000
- Intra-articular injection of ketorolac in the rat knee joint: effect on articular cartilage and synoviumBritish Journal of Anaesthesia, 1998
- Analgesia after day-case knee arthroscopy: double-blind study of intra-articular tenoxicam, intra-articular bupivacaine and placeboBritish Journal of Anaesthesia, 1997
- The Effect of Intraarticular Injection of Morphine and Bupivacaine on Postarthroscopic Pain ControlThe American Journal of Sports Medicine, 1995
- FENTANYL OR MAGNESIUM ANALGESIC SUPPLEMENTATION OF ANESTHESIAAnesthesiology, 1992
- Intraarticular Morphine, Bupivacaine, and Morphine/Bupivacaine for Pain Control after Knee VideoarthroscopyAnesthesiology, 1992
- Involvement of the mu-opiate receptor in peripheral analgesiaNeuroscience, 1989
- Biochemical and Metabolic Abnormalities in Articular Cartilage from Osteo-Arthritic Human HipsThe Journal of Bone & Joint Surgery, 1971