INCREASED VASCULAR PERMEABILITY INDUCED BY HUMAN PLASMIN
Open Access
- 1 November 1965
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 122 (5), 905-921
- https://doi.org/10.1084/jem.122.5.905
Abstract
Preparations of plasminogen, soluble in aqueous media, increased vascular permeability in guinea pig skin when activated by streptokinase or urokinase. The permeability-enhancing effect was inhibited by soybean trypsin inhibitor but not by triprolidine. Permeability-enhancing activity evolved when plasmin was incubated with fractions of plasma rich in prokinin. The experiments described suggest that plasmin exerts its permeability-increasing effect through the elaboration of kinins.Keywords
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