Pathogen-Host Associations and Predicted Range Shifts of Human Monkeypox in Response to Climate Change in Central Africa
Open Access
- 31 July 2013
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 8 (7), e66071
- https://doi.org/10.1371/journal.pone.0066071
Abstract
Climate change is predicted to result in changes in the geographic ranges and local prevalence of infectious diseases, either through direct effects on the pathogen, or indirectly through range shifts in vector and reservoir species. To better understand the occurrence of monkeypox virus (MPXV), an emerging Orthopoxvirus in humans, under contemporary and future climate conditions, we used ecological niche modeling techniques in conjunction with climate and remote-sensing variables. We first created spatially explicit probability distributions of its candidate reservoir species in Africa's Congo Basin. Reservoir species distributions were subsequently used to model current and projected future distributions of human monkeypox (MPX). Results indicate that forest clearing and climate are significant driving factors of the transmission of MPX from wildlife to humans under current climate conditions. Models under contemporary climate conditions performed well, as indicated by high values for the area under the receiver operator curve (AUC), and tests on spatially randomly and non-randomly omitted test data. Future projections were made on IPCC 4th Assessment climate change scenarios for 2050 and 2080, ranging from more conservative to more aggressive, and representing the potential variation within which range shifts can be expected to occur. Future projections showed range shifts into regions where MPX has not been recorded previously. Increased suitability for MPX was predicted in eastern Democratic Republic of Congo. Models developed here are useful for identifying areas where environmental conditions may become more suitable for human MPX; targeting candidate reservoir species for future screening efforts; and prioritizing regions for future MPX surveillance efforts.Keywords
This publication has 76 references indexed in Scilit:
- Ecological factors associated with dengue fever in a central highlands Province, VietnamBMC Infectious Diseases, 2011
- Using Remote Sensing to Map the Risk of Human Monkeypox Virus in the Congo BasinEcohealth, 2010
- Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of CongoProceedings of the National Academy of Sciences of the United States of America, 2010
- Climate Change and Risk of Leishmaniasis in North America: Predictions from Ecological Niche Models of Vector and Reservoir SpeciesPLoS Neglected Tropical Diseases, 2010
- Shifting suitability for malaria vectors across Africa with warming climatesBMC Infectious Diseases, 2009
- Impact of climate change and other factors on emerging arbovirus diseasesTransactions of the Royal Society of Tropical Medicine and Hygiene, 2009
- Contributions to accelerating atmospheric CO 2 growth from economic activity, carbon intensity, and efficiency of natural sinksProceedings of the National Academy of Sciences, 2007
- Global and regional drivers of accelerating CO 2 emissionsProceedings of the National Academy of Sciences, 2007
- A Space–Time Permutation Scan Statistic for Disease Outbreak DetectionPLoS Medicine, 2005
- New developments in museum-based informatics and applications in biodiversity analysisTrends in Ecology & Evolution, 2004