Increased ghrelin sensitivity and calorie consumption in subordinate monkeys is affected by short-term astressin B administration
- 17 July 2010
- journal article
- research article
- Published by Springer Science and Business Media LLC in Endocrine
- Vol. 38 (2), 227-234
- https://doi.org/10.1007/s12020-010-9378-5
Abstract
Animals chronically exposed to stressors with access to diets high in fat and sugar consume and prefer these diets, a result consistent with the association between stress and comfort food ingestion in humans. As social subordination in rhesus monkeys provides an ethologically relevant translational model of psychosocial stress, we tested the hypothesis that differences in food intake between dominant and subordinate female monkeys are due to corticotropin-releasing hormone-(CRH) induced alteration in sensitivity to ghrelin, a potent orexigenic signal. We assessed food intake of animals given a choice between a low (LCD) and high calorie diet (HCD) in response to 4-day treatment with the CRH receptor antagonist, astressin B, and to an acute treatment of ghrelin. Ghrelin stimulated intake of LCD in subordinates but did not further increase consumption of HCD, whereas ghrelin decreased LCD consumption without affecting HCD intake in dominant females. Astressin B decreased cortisol levels and increased preference for and intake of the HCD in subordinates and decreased calorie intake and HCD preference in dominant animals. These results suggest that increased caloric intake by subordinates may, in part, be explained by a greater sensitivity to postprandial increases in ghrelin and that CRH receptor antagonism leading to a decrease in cortisol has mixed effects on food choice depending on an individual’s stress background.Keywords
This publication has 74 references indexed in Scilit:
- Social Subordination and Polymorphisms in the Gene Encoding the Serotonin Transporter Enhance Estradiol Inhibition of Luteinizing Hormone Secretion in Female Rhesus Monkeys1Biology of Reproduction, 2009
- T-cell phenotypic and functional changes associated with social subordination and gene polymorphisms in the serotonin reuptake transporter in female rhesus monkeysBrain, Behavior, and Immunity, 2009
- Relationship Between Social Rank and Cortisol and Testosterone Concentrations in Male Cynomolgus Monkeys (Macaca fascicularis)Journal of Neuroendocrinology, 2008
- Quantifying food intake in socially housed monkeys: Social status effects on caloric consumptionPhysiology & Behavior, 2008
- The role of the posterior medial bed nucleus of the stria terminalis in modulating hypothalamic–pituitary–adrenocortical axis responsiveness to acute and chronic stressPsychoneuroendocrinology, 2008
- Polymorphisms in the serotonin reuptake transporter gene modify the consequences of social status on metabolic health in female rhesus monkeysPhysiology & Behavior, 2008
- Gender Differences in Associations Between Body Mass Index and DSM-IV Mood and Anxiety Disorders: Results from the National Epidemiologic Survey on Alcohol and Related ConditionsAnnals of Epidemiology, 2008
- Physiological and behavioral effects of social introduction on adult male rhesus macaquesAmerican Journal of Primatology, 2008
- Effects of stress on dietary preference and intake are dependent on access and stress sensitivityPhysiology & Behavior, 2007
- Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetiteJCI Insight, 2006