Palladium-Catalyzed Aerobic Oxidative Cross-Coupling Reactions of Terminal Alkynes with Alkylzinc Reagents
- 10 March 2010
- journal article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 132 (12), 4101-4103
- https://doi.org/10.1021/ja100630p
Abstract
With air as the oxidant, terminal alkynes can be directly cross-coupled with alkylzinc reagents in the presence of a Pd catalyst at room temperature. CO was found to be critical in gaining high chemical yields and selectivities. A wide range of alkynes and alkylzinc reagents were tested, and good to excellent yields were obtained.Keywords
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