CYCLOSPORINE, FK-506, RAPAMYCIN, AND OTHER IMMUNOMODULATORS
- 1 February 1996
- journal article
- review article
- Published by Elsevier BV in Rheumatic Disease Clinics of North America
- Vol. 22 (1), 133-154
- https://doi.org/10.1016/s0889-857x(05)70266-0
Abstract
Immunomodulatory agents represent a unique group of therapies that are not biologics and have relatively specific, noncytotoxic effects on the immune system. Cyclosporine has been the most widely tested of the immunomodulatory agents and shown efficacy in a variety of autoimmune diseases as well as monotherapy in established rheumatoid arthritis. FK-506 and rapamycin, agents similar to cyclosporine, are being tested in human transplantation, with only arthritis studies having been done in animals. Tilomisole, imuthiol, and mycophenolate mofetil have been studied in limited rheumatoid arthritis trials with positive effects. Although more specific and with manageable short-term side effects, this group of therapies requires more studies to establish their efficacy and long-term safety.Keywords
This publication has 105 references indexed in Scilit:
- Differential effects of cyclosporine and etretinate on serum cytokine levels in patients with psoriasisJournal of the American Academy of Dermatology, 1992
- Oral cyclosporine for severe chronic idiopathic urticaria and angioedemaJournal of the American Academy of Dermatology, 1991
- Management of Nephrotic Syndrome in ChildhoodDrugs, 1991
- Treatment of pyoderma gangrenosum with cyclosporine: Results in seven patientsJournal of the American Academy of Dermatology, 1991
- Effects of cyclosporine on immunologic mechanisms in psoriasisJournal of the American Academy of Dermatology, 1990
- Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.Proceedings of the National Academy of Sciences of the United States of America, 1990
- Intralesional cyclosporine in the treatment of psoriasis: A clinical, immunologic, and pharmacokinetic studyJournal of the American Academy of Dermatology, 1990
- Treatment of nine cases of pemphigus vulgaris with cyclosporineJournal of the American Academy of Dermatology, 1988
- Topical cyclosporins in psoriasisJournal of the American Academy of Dermatology, 1988
- Effects of cyclosporine in severe systemic lupus erythematosusThe Journal of Pediatrics, 1987