Palladium-Catalyzed Oxygenation of Unactivated sp3 C−H Bonds
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- 16 July 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 126 (31), 9542-9543
- https://doi.org/10.1021/ja046831c
Abstract
This communication describes a new palladium-catalyzed method for the oxygenation of unactivated sp3 C−H bonds. A wide variety of alkane substrates containing readily available oxime and/or pyridine directing groups are oxidized with extremely high levels of chemo-, regio-, and in some cases diastereoselectivity. The substrate scope of these reactions is discussed, and the high selectivities are rationalized on the basis of the requirements of putative palladium alkyl intermediates.This publication has 17 references indexed in Scilit:
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