Association of Visceral and Subcutaneous Adiposity with Kidney Function
Open Access
- 1 November 2008
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Clinical Journal of the American Society of Nephrology
- Vol. 3 (6), 1786-1791
- https://doi.org/10.2215/cjn.02490508
Abstract
Background and objectives: Obesity is a risk factor for incident chronic kidney disease (CKD). Visceral (VAT) and subcutaneous adipose tissue (SAT) may confer differential metabolic risk profiles. The relations of VAT and SAT were analyzed with CKD as estimated by creatinine- and cystatin-based estimating equations. Design, setting, participants, & measurements: Participants from the Framingham Offspring Study who underwent abdominal computed tomography for VAT and SAT quantification were included (n = 1299; 53% women; mean age 60 yr). CKD was defined as estimated GFR 2, as estimated using creatinine (n = 89) in the Modification of Diet in Renal Disease (MDRD) formula or by cystatin C (n = 136). Regression models evaluated the cross-sectional relations between VAT and SAT with CKD and cystatin C, with age and gender adjustment and cardiovascular risk factor adjustment. Results: Neither VAT nor SAT was associated with CKD as estimated by the MDRD equation. In contrast, both VAT and SAT were associated with CKD when defined using cystatin-based equations. The estimated decrease in estimated GFR by cystatin C per 1-SD increase of VAT was 1.9 ml/min per 1.73 m2 and for SAT was 2.6 ml/min per 1.73 m2 in a multivariable-adjusted model. Conclusions: VAT and SAT were associated with CKD when defined using cystatin C estimating equations but not when using a creatinine-based estimating equation. Mechanisms linking adipose tissue to cystatin C warrant further research.Keywords
This publication has 42 references indexed in Scilit:
- Overweight, Obesity, and Elevated Serum Cystatin C Levels in Adults in the United StatesAmerican Journal Of Medicine, 2008
- Estimating GFR Using Serum Cystatin C Alone and in Combination With Serum Creatinine: A Pooled Analysis of 3,418 Individuals With CKDAmerican Journal of Kidney Diseases, 2008
- Prevalence of Chronic Kidney Disease in the United StatesJAMA, 2007
- Adipocytokines and proinflammatory mediators from abdominal and epicardial adipose tissue in patients with coronary artery diseaseInternational Journal of Obesity, 2007
- Curbing the obesity epidemicThe Lancet, 2006
- The Adipose Renin-Angiotensin System Modulates Systemic Markers of Insulin Sensitivity and Activates the Intrarenal Renin-Angiotensin SystemJournal of Biomedicine and Biotechnology, 2006
- Chronic Kidney Disease and the Risks of Death, Cardiovascular Events, and HospitalizationNew England Journal of Medicine, 2004
- Predictors of New-Onset Kidney Disease in a Community-Based PopulationJama-Journal Of The American Medical Association, 2004
- Visceral Adiposity and the Risk of Impaired Glucose ToleranceDiabetes Care, 2003
- Editorial boardAmerican Journal of Kidney Diseases, 2003