Comparison of Immune Restoration in Early versus Late Alpha Interferon Therapy against Hepatitis C Virus
Open Access
- 1 October 2010
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 84 (19), 10429-10435
- https://doi.org/10.1128/jvi.01094-10
Abstract
Early alpha interferon (IFN-α) therapy against hepatitis C virus (HCV) rescues polyfunctional, virus-specific memory CD8 + T cells, but whether immune restoration is possible during late therapy remains controversial. We compared immune restoration of HCV-specific memory T cells in patients who cleared HCV infection spontaneously and following early or late IFN therapy. Multifunctional CD4 + and CD8 + memory T cells were detected in spontaneous resolvers and in individuals treated early following an acute infection. In contrast, limited responses were detected in patients treated during chronic infection, and the phenotype of HCV-specific cells was influenced by autologous viral sequences. Our data suggest that irreversible damage to the HCV-specific memory T-cell response is associated with chronic HCV infection.This publication has 29 references indexed in Scilit:
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