Adaptive β-Cell Proliferation Is Severely Restricted With Advanced Age
Open Access
- 5 March 2009
- journal article
- Published by American Diabetes Association in Diabetes
- Vol. 58 (6), 1365-1372
- https://doi.org/10.2337/db08-1198
Abstract
OBJECTIVE Regeneration of the insulin-secreting β-cells is a fundamental research goal that could benefit patients with either type 1 or type 2 diabetes. β-Cell proliferation can be acutely stimulated by a variety of stimuli in young rodents. However, it is unknown whether this adaptive β-cell regeneration capacity is retained into old age.Keywords
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