Drinking Water Disinfection By-Product Exposure and Duration of Gestation
- 1 September 2008
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Epidemiology
- Vol. 19 (5), 738-746
- https://doi.org/10.1097/ede.0b013e3181812beb
Abstract
Recent studies suggest elevated exposure to drinking water disinfection by-products (DBPs) may be associated with decreased risk of preterm birth. We examined this association for exposure to total trihalomethanes (TTHMs), 5 haloacetic acids (HAA5), and total organic halides. Analysis included 2039 women in a prospective pregnancy study conducted from 2000 through 2004 in 3 study sites. Water samples were collected and analyzed for DBP concentrations. Participant data were collected through interviews, an early ultrasound, and birth records. We assessed the associations between DBPs and preterm birth (<37-weeks' gestation) using log-binomial regression. Discrete-time hazard analysis was used to model the conditional odds of delivery each week in relation to DBP exposure. Average second trimester DBP levels were associated with lower risk of preterm birth. Adjusted risk ratios for TTHM levels of 33.1-55.0, 55.1-66.3, 66.4-74.8, and 74.9-108.8 microg/L versus 2.2-4.6 microg/L were 0.8 (95% confidence intervals = 0.5-1.3), 0.9 (0.6-1.4), 0.7 (0.4-1.1), and 0.5 (0.3-0.9), respectively. Risk ratios for HAA5 levels of 17.9-22.0, 22.1-31.5, 31.6-40.4, and 40.5-52.8 microg/L versus 0-0.9 microg/L were 1.1 (0.8-1.7), 0.8 (0.5-1.2), 0.5 (0.3-0.8), and 0.7 (0.4-1.1), respectively. The conditional odds of delivery each week were decreased for the highest TTHM and HAA5 exposure groups versus the low exposure group for gestational weeks 33-40. The probability of preterm birth was not increased with high DBP exposure.Keywords
This publication has 31 references indexed in Scilit:
- Updated weight of evidence for an association between adverse reproductive and developmental effects and exposure to disinfection by-productsRegulatory Toxicology and Pharmacology, 2006
- Disinfection Byproducts and Bladder CancerEpidemiology, 2004
- Effect of trihalomethane exposure on fetal developmentOccupational and Environmental Medicine, 2003
- Drinking water contaminants and adverse pregnancy outcomes: a review.Environmental Health Perspectives, 2002
- Chlorination disinfection byproducts in water and their association with adverse reproductive outcomes: a reviewOccupational and Environmental Medicine, 2000
- Trihalomethanes in Public Water Supplies and Adverse Birth OutcomesEpidemiology, 1999
- Drinking Water Source and Chlorination Byproducts II. Risk of Colon and Rectal CancersEpidemiology, 1998
- Drinking water and pregnancy outcome in central North Carolina: source, amount, and trihalomethane levels.Environmental Health Perspectives, 1995
- Public Drinking Water Contamination and Birth OutcomesAmerican Journal of Epidemiology, 1995
- The Association of Waterborne Chloroform with Intrauterine Growth RetardationEpidemiology, 1992