Association between Exposure to Environmental Tobacco Smoke and Biomarkers of Oxidative Stress Among Patients Hospitalised with Acute Myocardial Infarction
Open Access
- 5 December 2013
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 8 (12), e81209
- https://doi.org/10.1371/journal.pone.0081209
Abstract
To determine whether exposure to environmental tobacco smoke was associated with oxidative stress among patients hospitalised for acute myocardial infarction. An existing cohort study of 1,261 patients hospitalised for acute myocardial infarction. Nine acute hospitals in Scotland. Sixty never smokers who had been exposed to environmental tobacco smoke (admission serum cotinine ≥3.0 ng/mL) were compared with 60 never smokers who had not (admission serum cotinine ≤0.1 ng/mL). None. Three biomarkers of oxidative stress (protein carbonyl, malondialdehyde (MDA) and oxidised low-density lipoprotein (ox-LDL)) were measured on admission blood samples and adjusted for potential confounders. After adjusting for baseline differences in age, sex and socioeconomic status, exposure to environmental tobacco smoke was associated with serum concentrations of both protein carbonyl (beta coefficient 7.96, 95% CI 0.76, 15.17, p = 0.031) and MDA (beta coefficient 10.57, 95% CI 4.32, 16.81, p = 0.001) but not ox-LDL (beta coefficient 2.14, 95% CI −8.94, 13.21, p = 0.703). Exposure to environmental tobacco smoke was associated with increased oxidative stress. Further studies are requires to explore the role of oxidative stress in the association between environmental tobacco smoke and myocardial infarction.This publication has 31 references indexed in Scilit:
- Differential oxidative stress response in young children and the elderly following exposure to PM2.5Environmental Health and Preventive Medicine, 2008
- Smoke-free Legislation and Hospitalizations for Acute Coronary SyndromeThe New England Journal of Medicine, 2008
- Increased DNA damage in children caused by passive smoking as assessed by comet assay and oxidative stressMutation Research - Genetic Toxicology and Environmental Mutagenesis, 2007
- Chronic exposure to second hand smoke and 30-day prognosis of patients hospitalised with acute coronary syndromes: the Greek study of acute coronary syndromesHeart, 2007
- Secondhand smoke as an acute threat for the cardiovascular system: a change in paradigmEuropean Heart Journal, 2005
- Increased oxidative stress in infants exposed to passive smokingEuropean Journal of Pediatrics, 2005
- Passive smoking impairs endothelium-dependent relaxation of isolated rabbit arteries.2000
- Oxidized LDL and Malondialdehyde-Modified LDL in Patients With Acute Coronary Syndromes and Stable Coronary Artery DiseaseCirculation, 1998
- Environmental tobacco smoke in the workplace induces oxidative stress in employees, including increased production of 8-hydroxy-2'-deoxyguanosine.1998
- Lipid peroxidation of circulating low density lipoproteins with age, smoking and in peripheral vascular diseaseAtherosclerosis, 1995