Roles of sphingosine-1-phosphate signaling in angiogenesis
Open Access
- 1 January 2010
- journal article
- Published by Baishideng Publishing Group Inc. in World Journal of Biological Chemistry
- Vol. 1 (10), 298-306
- https://doi.org/10.4331/wjbc.v1.i10.298
Abstract
Sphingosine-1-phosphate (S1P) is a blood-borne lipid mediator with pleiotropic biological activities. S1P acts via the specific cell surface G-protein-coupled receptors, S1P1-5. S1P1 and S1P2 were originally identified from vascular endothelial cells (ECs) and smooth muscle cells, respectively. Emerging evidence shows that S1P plays crucial roles in the regulation of vascular functions, including vascular formation, barrier protection and vascular tone via S1P1, S1P2 and S1P3. In particular, S1P regulates vascular formation through multiple mechanisms; S1P exerts both positive and negative effects on angiogenesis and vascular maturation. The positive and negative effects of S1P are mediated by S1P1 and S1P2, respectively. These effects of S1P1 and S1P2 are probably mediated by the S1P receptors expressed in multiple cell types including ECs and bone-marrow-derived cells. The receptor-subtype-specific, distinct effects of S1P favor the development of novel therapeutic tactics for antitumor angiogenesis in cancer and therapeutic angiogenesis in ischemic diseases.Keywords
This publication has 75 references indexed in Scilit:
- Sphingosine kinase regulates the rate of endothelial progenitor cell differentiationBlood, 2009
- Up-regulating Sphingosine 1-Phosphate Receptor-2 Signaling Impairs Chemotactic, Wound-healing, and Morphogenetic Responses in Senescent Endothelial CellsPublished by Elsevier BV ,2008
- The vascular S1P gradient—Cellular sources and biological significanceBiochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2008
- Sphingosine-1-phosphate regulation of mammalian developmentBiochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2008
- A Catalytic Role for Proangiogenic Marrow-Derived Cells in Tumor NeovascularizationCancer Cell, 2008
- The lysophospholipid mediator sphingosine-1-phosphate promotes angiogenesis in vivo in ischaemic hindlimbs of miceCardiovascular Research, 2008
- Maternal disturbance in activated sphingolipid metabolism causes pregnancy loss in miceJCI Insight, 2007
- Essential role of sphingosine 1–phosphate receptor 2 in pathological angiogenesis of the mouse retinaJCI Insight, 2007
- Negative regulation of endothelial morphogenesis and angiogenesis by S1P2 receptorBiochemical and Biophysical Research Communications, 2006
- Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradientBiochemical Journal, 2006