Pentagon drawing and neuropsychological performance in Dementia with Lewy Bodies, Alzheimer's disease, Parkinson's disease and Parkinson's disease with dementia
- 25 February 2004
- journal article
- research article
- Published by Wiley in International Journal of Geriatric Psychiatry
- Vol. 19 (4), 371-377
- https://doi.org/10.1002/gps.1094
Abstract
Objectives Early and accurate diagnosis of Dementia with Lewy Bodies (DLB) to allow the appropriate clinical treatment is a priority, given reports of severe neuroleptic sensitivity and a preferential response to cholinesterase inhibitors in these patients. There have been suggestions that constructional apraxia is prevalent in DLB, and may provide a sensitive marker of the disease. Methods This study examined the pentagon drawings of 100 DLB patients, 50 Alzheimer's disease (AD) patients, 81 Parkinson's disease (PD) patients of whom 36 suffered from dementia (PDD). Performance on this task was correlated with cognitive performance on the MMSE and CAMCOG scales. Results Patients with DLB were found to draw significantly worse pentagons than those with AD or PD, but not those with PDD. Drawing scores were significantly correlated with MMSE scores for the AD and PDD groups but not those with DLB. More detailed analysis of the neuropsychological correlates of constructional performance for patients with AD and DLB, revealed that those with AD showed a broad cognitive basis to their impairment, in DLB drawing was linked only to perception and praxis. Conclusions This study has suggests that DLB subjects show an impairment of pentagon copying that is dissociable from more global cognitive impairments, whereas PD patients are relatively unimpaired on pentagon copying and AD and PDD patients show a linkage of their impairment in copying with more global cognitive deficits. Copyright © 2004 John Wiley & Sons, Ltd.Keywords
This publication has 30 references indexed in Scilit:
- Dementia with Lewy BodiesDrugs & Aging, 2001
- Brain perfusion scintigraphy with99mTc-HMPAO or99mTc-ECD and123I-β-CIT single-photon emission tomography in dementia of the Alzheimer-type and diffuse Lewy body diseaseEuropean Journal of Nuclear Medicine and Molecular Imaging, 1997
- Motor and cognitive function in Lewy body dementia: comparison with Alzheimer's and Parkinson's diseases.Journal of Neurology, Neurosurgery & Psychiatry, 1997
- Copying and handwriting ability in the screening of cognitive dysfunction in old ageArchives of Gerontology and Geriatrics, 1996
- The epidemiology of Parkinson's disease in the county of Rogaland, NorwayMovement Disorders, 1995
- A comparison of clock and pentagon drawing in Alzheimer's diseaseInternational Journal of Geriatric Psychiatry, 1995
- The Lewy-Body Variant of Alzheimer's DiseaseThe British Journal of Psychiatry, 1993
- Operational criteria for senile dementia of Lewy body type (SDLT)Psychological Medicine, 1992
- Parkinson's disease as community health problem: study in Norwegian nursing homes. The Norwegian Study Group of Parkinson's Disease in the Elderly.BMJ, 1991
- “Mini-mental state”: A practical method for grading the cognitive state of patients for the clinicianJournal of Psychiatric Research, 1975