Interleukin-10: A Key Cytokine in Depression?
Open Access
- 16 August 2009
- journal article
- Published by Hindawi Limited in Cardiovascular Psychiatry and Neurology
- Vol. 2009, 1-5
- https://doi.org/10.1155/2009/187894
Abstract
An increasing body of evidence implicates proinflammatory cytokines in psychiatric disorders, namely, in depression. Of notice, recent studies showed that anti-inflammatory cytokines, such as IL-10, also modulate depressive-like behavior. In this article, we propose that the anti-inflammatory cytokine IL-10 is a putative link between two of the most widely reported phenomenon observed in depressed patients: the disruption of the hypothalamic-pituitary-adrenal axis and the imbalanced production of cytokines. If so, IL-10 might represent a novel target for antidepressant therapy.Keywords
Funding Information
- Fundação para a Ciência e a Tecnologia (SFRH/BD/24539/2005, PTDC/SAU-NEU/72699/2006)
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