Osteoarthritis subpopulations and implications for clinical trial design
Open Access
- 1 January 2011
- journal article
- review article
- Published by Springer Science and Business Media LLC in Arthritis Research & Therapy
- Vol. 13 (2), 213
- https://doi.org/10.1186/ar3299
Abstract
Treatment guidelines for osteoarthritis have stressed the need for research on clinical predictors of response to different treatments. However, identifying such clinical predictors of response is less easy than it seems, and there is not a given classification of osteoarthritis subpopulations. This review article highlights the key methodical issues when analyzing and designing clinical studies to detect important subgroups with respect to treatment effect. In addition, we discuss the main osteoarthritis subpopulations and give examples of how specific treatment effects in these subpopulations have been assessed.Keywords
This publication has 81 references indexed in Scilit:
- Low back pain and other musculoskeletal pain comorbidities in individuals with symptomatic osteoarthritis of the knee: Data from the osteoarthritis initiativeArthritis Care & Research, 2010
- Identifying different osteoarthritis phenotypes through epidemiologyOsteoarthritis and Cartilage, 2010
- Varus and valgus alignment and incident and progressive knee osteoarthritisAnnals Of The Rheumatic Diseases, 2010
- Back Pain and Total Hip Arthroplasty: A Prospective Natural History StudyClinical Orthopaedics & Related Research, 2010
- Osteoarthritis of the hip or knee: which coexisting disorders are disabling?Clinical Rheumatology, 2010
- The genetic influence on radiographic osteoarthritis is site specific at the hand, hip and kneeRheumatology, 2009
- Effect of therapeutic exercise for hip osteoarthritis pain: Results of a meta‐analysisArthritis Care & Research, 2008
- Does knee malalignment mediate the effects of quadriceps strengthening on knee adduction moment, pain, and function in medial knee osteoarthritis? A randomized controlled trialArthritis Care & Research, 2008
- OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelinesOsteoarthritis and Cartilage, 2008
- Body mass index associated with onset and progression of osteoarthritis of the knee but not of the hip: The Rotterdam StudyAnnals Of The Rheumatic Diseases, 2006