Does the addition of cement improve the rate of local recurrence after curettage of giant cell tumours in bone?
- 1 December 2011
- journal article
- research article
- Published by British Editorial Society of Bone & Joint Surgery in The Journal of Bone and Joint Surgery. British volume
- Vol. 93-B (12), 1665-1669
- https://doi.org/10.1302/0301-620x.93b12.27663
Abstract
We retrospectively compared the outcome after the treatment of giant cell tumours of bone either with curettage alone or with adjuvant cementation. Between 1975 and 2008, 330 patients with a giant cell tumour were treated primarily by intralesional curettage, with 84 (25%) receiving adjuvant bone cement in the cavity. The local recurrence rate for curettage alone was 29.7% (73 of 246) compared with 14.3% (12 of 84) for curettage and cementation (p = 0.001). On multivariate analysis both the stage of disease and use of cement were independent significant factors associated with local recurrence. The use of cement was associated with a higher risk of the subsequent need for joint replacement. In patients without local recurrence, 18.1% (13 of 72) of those with cement needed a subsequent joint replacement compared to 2.3% (4 of 173) of those without cement (p = 0.001). In patients who developed local recurrence, 75.0% (9 of 12) of those with previous cementation required a joint replacement, compared with 45.2% (33 of 73) of those without cement (p = 0.044).Keywords
This publication has 24 references indexed in Scilit:
- Giant Cell Tumor of Bone: Risk Factors for RecurrenceClinical Orthopaedics and Related Research, 2010
- Joint Preservation after Extensive Curettage of Knee Giant Cell TumorsClinical Orthopaedics and Related Research, 2009
- Bone defects following curettage do not necessarily need augmentationActa Orthopaedica, 2009
- Cement is recommended in intralesional surgery of giant cell tumors: A Scandinavian Sarcoma Group study of 294 patients followed for a median time of 5 yearsActa Orthopaedica, 2008
- Comparison of the degenerative changes in weight-bearing joints following cementing or grafting techniques in giant cell tumour patients: medium-term resultsInternational Orthopaedics, 2006
- Management of grade III giant cell tumors of bonesJournal of Surgical Oncology, 2005
- Giant-cell tumour of boneThe Journal of Bone and Joint Surgery. British volume, 2004
- Subchondral defects in caprine femora augmented with in situ setting hydroxyapatite cement, polymethylmethacrylate, or autogenous bone graft: biomechanical and histomorphological analysis after two-yearsJournal of Orthopaedic Research, 2002
- Thermal Aspects of the Use of Polymethylmethacrylate in Large Metaphyseal Defects in BoneClinical Orthopaedics and Related Research, 1993
- Favourable results of acrylic cementation for giant cell tumorsActa Orthopaedica, 1984