Modulation of Rho GTPases by type III secretion system translocated effectors of Yersinia
- 17 September 2004
- book chapter
- review article
- Published by Springer Science and Business Media LLC in Reviews of physiology, biochemistry and pharmacology
- Vol. 152, 65-77
- https://doi.org/10.1007/s10254-004-0035-3
Abstract
Pathogenic species of the bacterial genus Yersinia subdue the immune system to proliferate and spread within the host organism. For this purpose yersiniae employ a type III secretion apparatus which governs injection of six effector proteins (Y ersinia outer proteins; Yops) into host cells. Yops control various regulatory and signalling proteins in a unique and highly specific manner. YopE, YopT, and YpkA/YopO modulate the activity of Rho GTP-binding proteins, whereas YopH dephosphorylates phospho-tyrosine residues in focal adhesion proteins. Furthermore, YopP/YopJ and YopM affect cell survival/apoptosis and cell proliferation, respectively. In this review the focus will be on the biochemistry and cellular effects of YopT, YopE, YopO/YpkA, and YopH.Keywords
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