Allergic reactions to β-lactams
- 22 December 2005
- journal article
- review article
- Published by Informa UK Limited in Expert Opinion on Drug Safety
- Vol. 5 (1), 31-48
- https://doi.org/10.1517/14740338.5.1.31
Abstract
Allergy to β-lactam antibiotics is the most frequent cause of drug-induced immunological reactions, although the prevalence is not exactly known. IgE- and T-cell-dependent responses are the main mechanisms involved, although other immunological mechanisms can also participate, especially in haematological abnormalities, such as immune haemolytic anaemia or thrombocytopoenia. Aside from their frequency, the clinical entities reported nowadays have changed little since penicillin was first used. The variation in β-lactams consumption through the year has modified the pattern and specificities of allergic reactions for IgE and T cell responses. Benzylpenicillin is no longer the β-lactams most frequently prescribed and other chemical structures, with new or modified haptens, have progressively replaced it. This is relevant for the diagnostic evaluation and management of β-lactam hypersensitivity.Keywords
This publication has 99 references indexed in Scilit:
- Immediate allergic reactions to cephalosporins and penicillins and their cross‐reactivity in childrenPediatric Allergy and Immunology, 2005
- Cefuroxime-induced immune hemolysisThe Journal of Pediatrics, 2004
- Determination of the incidence of sensitization after penicillin skin testingAnnals of Allergy, Asthma & Immunology, 2003
- General considerations for skin test procedures in the diagnosis of drug hypersensitivityAllergy, 2002
- T-cell involvement in drug-induced acute generalized exanthematous pustulosisJCI Insight, 2001
- Selective type-1 hypersensitivity to cefuroximeJournal of Allergy and Clinical Immunology, 1998
- β-Lactam drug allergens: Fine structural recognition patterns of cephalosporin-reactive IgE antibodiesJournal of Molecular Recognition, 1996
- Evaluation of adverse cutaneous reactions to aminopenicillins with emphasis on those manifested by maculopapular rashesAllergy, 1995
- Routine elective penicillin allergy skin testing in children and adolescents: study of sensitizationJournal of Allergy and Clinical Immunology, 1984
- A new and simple radioimmunoassay method for the determination of IgEImmunochemistry, 1972