Enduring Changes in Dopamine Receptor Cells of Pups from Drug Administration to Pregnant and Nursing Rats
- 16 March 1979
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 203 (4385), 1133-1135
- https://doi.org/10.1126/science.570724
Abstract
A decrease in specific [3H]spiroperidol binding to rat caudate tissue and a parallel decrease in sensitivity to apomorphine in eliciting stereotyped behavior was observed in the offspring of rat mothers treated with either haloperidol or alpha-methyl-p-tyrosine-methyl ester during pregnancy. In contrast, evidence of increased dopamine-receptor sensitivity was observed in the pups if haloperidol was administered to their mothers postpartum during nursing rather than during pregnancy.This publication has 18 references indexed in Scilit:
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