Arterial Stiffness in Mild-to-Moderate CKD
Open Access
- 1 September 2009
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of the American Society of Nephrology
- Vol. 20 (9), 2044-2053
- https://doi.org/10.1681/asn.2009010074
Abstract
Whether arterial stiffness correlates with mild-to-moderate CKD and albuminuria in the community is unclear. We studied the association between arterial stiffness and mild-to-moderate CKD and albuminuria in the Framingham Heart Study. CKD was present in 6.7% (181 of 2682) of participants and microalbuminuria was present in 8.2% (479 of 5818). The measures of arterial stiffness were the carotid femoral pulse wave velocity, forward pressure wave amplitude, central pulse pressure, augmentation pressure, augmentation index, and mean arterial pressure. In cross-sectional analyses, arterial stiffness did not associate with CKD (defined by estimated GFR 2) in either age- and gender-adjusted or multivariable-adjusted linear regression models. Carotid femoral pulse wave velocity associated with both urinary albumin-to-creatinine ratio and microalbuminuria (P < 0.0001 after multivariable adjustment). In longitudinal analyses, we used logistic regression models to examine the associations between baseline arterial stiffness measures (exposure variables) and incident CKD or microalbuminuria (n = 1675 for CKD analyses and n = 1252 for microalbuminuria analyses). Baseline arterial measures did not associate with incident CKD or incident microalbuminuria. In summary, arterial stiffness correlates with albuminuria but not with mild-to-moderate CKD.Keywords
This publication has 52 references indexed in Scilit:
- Relations of Measures of Endothelial Function and Kidney Disease: The Framingham Heart StudyAmerican Journal of Kidney Diseases, 2008
- Relations of Inflammatory Biomarkers and Common Genetic Variants With Arterial Stiffness and Wave ReflectionHypertension, 2008
- Estimating GFR Using Serum Cystatin C Alone and in Combination With Serum Creatinine: A Pooled Analysis of 3,418 Individuals With CKDAmerican Journal of Kidney Diseases, 2008
- Prevalence of Chronic Kidney Disease in the United StatesJAMA, 2007
- Long-Term Trandolapril Treatment Is Associated With Reduced Aortic StiffnessHypertension, 2007
- Triangulating the Peaks of Arterial PressureHypertension, 2006
- Stiffness of Capacitive and Conduit ArteriesHypertension, 2005
- Chronic Kidney Disease and the Risks of Death, Cardiovascular Events, and HospitalizationThe New England Journal of Medicine, 2004
- Predictors of New-Onset Kidney Disease in a Community-Based PopulationJAMA, 2004
- Effects of aging on changing arterial compliance and left ventricular load in a northern Chinese urban community.Circulation, 1983