Vaccines as a trigger for myopathies
- 30 October 2009
- journal article
- review article
- Published by SAGE Publications in Lupus
- Vol. 18 (13), 1213-1216
- https://doi.org/10.1177/0961203309345734
Abstract
Vaccines are considered to be among the greatest medical discoveries, credited with the virtual eradication of some diseases and the consequent improved survival and quality of life of the at-risk population. With that, vaccines are among the environmental factors implicated as triggers for the development of inflammatory myopathies. The sporadic reports on vaccineinduced inflammatory myopathies include cases of hepatitis B virus, bacillus Calmette—Guérin, tetanus, influenza, smallpox, polio, diphtheria, diphtheria—pertussis—tetanus, combination of diphtheria with scarlet fever and diphtheria—pertussis—tetanus with polio vaccines. However, a significant increase in the incidence of dermatomyositis or polymyositis after any massive vaccination campaign has not been reported in the literature. In study patients with inflammatory myopathies, no recent immunization was recorded in any of the patients. Moreover, after the 1976 mass flu vaccination, no increase in the incidence of inflammatory myopathies was observed. Although rare, macrophagic myofasciitis has been reported following vaccination and is attributed to the aluminium hydroxide used as an adjuvant in some vaccines. Prospective multicenter studies are needed to identify potential environmental factors, including vaccines, as potential triggers for inflammatory myopathies. Lupus (2009) 18, 1213—1216.This publication has 18 references indexed in Scilit:
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