Comparing long-term results of PASAT and SDMT scores in relation to neuropsychological testing in multiple sclerosis
- 9 September 2013
- journal article
- research article
- Published by SAGE Publications in Multiple Sclerosis Journal
- Vol. 20 (4), 481-488
- https://doi.org/10.1177/1352458513501570
Abstract
Background and objectives: The Symbol Digit Modalities Test (SDMT) shows advantages over the Paced Auditory Serial Addition Test (PASAT) as a cognitive test in patients with multiple sclerosis (MS). To determine which of these tests is most valid and reliable over time as an indicator of the cognitive state of MS patients, long-term test results of both tests were compared in relation to scores of the Brief Repeatable Battery of Neuropsychological tests (BRBN). Methods: For 485 MS patients visiting the VU University Medical Center Amsterdam for different research projects, a total number of 1078 visits with BRBN (including PASAT and SDMT) was planned. Observed and model-based correlations were used to calculate the construct validity of the SDMT and PASAT 3 seconds test (PASAT3) by comparing correlations with the BRBN-sumscore. The test-retest reliability of each test was also computed. Results: For the construct validity, higher correlations were found between SDMT and BRBN compared to PASAT3 and BRBN, especially for the model-based correlations at baseline. The reliability of the measurements was good for all instruments, with the highest coefficients for the SDMT. Conclusion: As a single assessment tool for cognition in MS, the SDMT is more valid and reliable compared to PASAT3.Keywords
This publication has 31 references indexed in Scilit:
- Brief International Cognitive Assessment for MS (BICAMS): international standards for validationBMC Neurology, 2012
- Recommendations for a Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS)Multiple Sclerosis Journal, 2011
- Evaluation of the symbol digit modalities test (SDMT) and MS neuropsychological screening questionnaire (MSNQ) in natalizumab-treated MS patients over 48 weeksMultiple Sclerosis Journal, 2010
- Psychometrics and normative data for the Multiple Sclerosis Functional Composite: replacing the PASAT with the Symbol Digit Modalities TestMultiple Sclerosis Journal, 2009
- Sensitivity of conventional memory tests in multiple sclerosis: comparing the Rao Brief Repeatable Neuropsychological Battery and the Minimal Assessment of Cognitive Function in MSMultiple Sclerosis Journal, 2009
- Repeated assessment of neuropsychological deficits in multiple sclerosis using the Symbol Digit Modalities Test and the MS Neuropsychological Screening QuestionnaireMultiple Sclerosis Journal, 2008
- A comprehensive review of the Paced Auditory Serial Addition Test (PASAT)Archives of Clinical Neuropsychology, 2006
- Predicting quality of life in multiple sclerosis: accounting for physical disability, fatigue, cognition, mood disorder, personality, and behavior changeJournal of the Neurological Sciences, 2005
- Cognitive dysfunction in multiple sclerosis.Neurology, 1991
- Rating neurologic impairment in multiple sclerosisNeurology, 1983