Since ancient times, the two ancient civilizations of China and India have had a long history of trade exchanges, and such trade exchanges have left an important mark in the history of Sino-India relations. Chronologically，this article takes the Sino-Indian trade exchanges as a research perspective to outline two thousand years of trade history between two countries. From the Sino-Indian Business Road that began in the Qin Dynasty and Han Dynasty to the origin of the Silk Road on which Zhang Qian went to the Western Regions as an envoy, explored the Sino-India-Tibet Road and Maritime Silk Road trade; analyzed the opium trade between China, Britain and India in modern times. At the same time, it uses the founding of People’s Republic of China, the Sino-Indian War, the Belt and Road Initiative and the important events of the global epidemic as nodes to describe the development of Sino-Indian trade. In the long history, this kind of rich trade history also shows that China and India are more likely and should establish a better and more extensive trade cooperation relationship, and learn to effectively deal with the turmoil. This will provide reference for operating the trade activities between the two countries.