Expression of Viral MicroRNAs in Epstein-Barr Virus-Associated Gastric Carcinoma
Open Access
- 15 January 2007
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 81 (2), 1033-1036
- https://doi.org/10.1128/jvi.02271-06
Abstract
Epstein-Barr virus (EBV) is associated with about 6 to 16% of gastric carcinoma cases worldwide. Expression of the EBV microRNAs (miRNAs) was observed in B cells and nasopharyngeal carcinoma cells infected with EBV. However, it is not clear if the EBV miRNAs are expressed in EBV-associated gastric carcinomas (EBVaGCs). We found that BART miRNAs but not BHRF1 miRNAs were expressed in EBV-infected gastric carcinoma cell lines and the tumor tissues from patients as well as the animal model. The expression of viral miRNAs in EBVaGCs suggests that these EBV miRNAs may play important roles in the tumorigenesis of EBVaGCs.This publication has 21 references indexed in Scilit:
- BIC and miR‐155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomasThe Journal of Pathology, 2005
- MicroRNA-21 Is an Antiapoptotic Factor in Human Glioblastoma CellsCancer Research, 2005
- The functions of animal microRNAsNature, 2004
- Identification of Virus-Encoded MicroRNAsScience, 2004
- A naturally derived gastric cancer cell line shows latency I Epstein–Barr virus infection closely resembling EBV-associated gastric cancerVirology, 2004
- MicroRNAs: Genomics, Biogenesis, Mechanism, and FunctionCell, 2004
- Upregulation of the truncated basic hair keratin 1(hHb1‐ΔN) in carcinoma cells by Epstein‐Barr virus (EBV)International Journal of Cancer, 2003
- miRNAs: Micro Managers of Programmed Cell DeathCurrent Biology, 2003
- A uniform system for microRNA annotationRNA, 2003
- Epstein-Barr virus and gastric carcinomaMolecular Pathology, 2000