Characterization of a Suppressor-Cell Leukemia
- 12 January 1978
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 298 (2), 66-72
- https://doi.org/10.1056/nejm197801122980202
Abstract
To characterize the suppressor activity of neoplastic T cells from a child with acute lymphoblastic leukemia and hypogammaglobulinemia, we applied an in vitro assay that determines the capacity of pokeweed-mitogen-stimulated lymphocytes to mature into immunoglobulin-secreting cells. The geometric mean synthesis by peripheral blood lymphocytes from 12 normal persons was 3200 ng for IgM, 2447 ng for IgG and 1825 ng for IgA (2 X 106 cells per 12 days in culture). The patient's leukemic cells produced no detectable immunoglobulin and depressed the immunoglobulin production of normal lymphocytes by 85 to 100 per cent in co-culture experiments. However, suppression was observed only when co-operating normal T cells were present. Prior irradiation of either the leukemic T cells or the co-operating normal T cells nullified the suppressor effect. Therefore, an interaction between at least two different T-cell subsets may be required for the generation of suppressor effector T cells in man. (N Engl J Med 298:66–72, 1978)This publication has 25 references indexed in Scilit:
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