Hepatitis B virus–cell interactions and pathogenesis
- 26 February 2008
- journal article
- review article
- Published by Wiley in Journal of Cellular Physiology
- Vol. 216 (2), 289-294
- https://doi.org/10.1002/jcp.21416
Abstract
Like all viruses, hepatitis B virus (HBV) replication and pathogenesis depends on the critical interplay between viral and host factors. In this review, we will focus on the recent progress in understanding the virus–host interactions at the level of the infected cell. These interactions include the requirement of cellular chaperones for the initiation of HBV reverse transcription, the role of the HBV X protein (HBx) in modifying viral and cellular transcription and signaling, the formation of the HBV episomal DNA and its epigenetic regulation in viral persistence, and the cellular factors involved in viral entry, nucleocapsid maturation, and virion secretion. J. Cell. Physiol. 216: 289–294, 2008.Keywords
This publication has 140 references indexed in Scilit:
- Inhibition of Hepadnavirus Reverse Transcriptase-ε RNA Interaction by Porphyrin CompoundsJournal of Virology, 2008
- Characterization of the Intracellular Deproteinized Relaxed Circular DNA of Hepatitis B Virus: an Intermediate of Covalently Closed Circular DNA FormationJournal of Virology, 2007
- Formation of Hepatitis B Virus Covalently Closed Circular DNA: Removal of Genome-Linked ProteinJournal of Virology, 2007
- Involvement of host cellular multivesicular body functions in hepatitis B virus buddingProceedings of the National Academy of Sciences, 2007
- Deamination-Independent Inhibition of Hepatitis B Virus Reverse Transcription by APOBEC3GJournal of Virology, 2007
- Regulation of Hepadnavirus Reverse Transcription by Dynamic Nucleocapsid PhosphorylationJournal of Virology, 2007
- Therapy for chronic hepatitis B: the earlier, the better?Trends in Microbiology, 2004
- Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif proteinNature, 2002
- Specific Association of Human Telomerase Activity with Immortal Cells and CancerScience, 1994
- Frequent activation of N-myc genes by hepadnavirus insertion in woodchuck liver tumoursNature, 1990