Intrinsic and extrinsic factors influencing the clinical course of B-cell chronic lymphocytic leukemia: prognostic markers with pathogenetic relevance
Open Access
- 28 August 2009
- journal article
- review article
- Published by Springer Science and Business Media LLC in Journal of Translational Medicine
- Vol. 7 (1), 76
- https://doi.org/10.1186/1479-5876-7-76
Abstract
B-cell chronic lymphocytic leukemia (CLL), the most frequent leukemia in the Western world, is characterized by extremely variable clinical courses with survivals ranging from 1 to more than 15 years. The pathogenetic factors playing a key role in defining the biological features of CLL cells, hence eventually influencing the clinical aggressiveness of the disease, are here divided into "intrinsic factors", mainly genomic alterations of CLL cells, and "extrinsic factors", responsible for direct microenvironmental interactions of CLL cells; the latter group includes interactions of CLL cells occurring via the surface B cell receptor (BCR) and dependent to specific molecular features of the BCR itself and/or to the presence of the BCR-associated molecule ZAP-70, or via other non-BCR-dependent interactions, e.g. specific receptor/ligand interactions, such as CD38/CD31 or CD49d/VCAM-1. A putative final model, discussing the pathogenesis and the clinicobiological features of CLL in relationship of these factors, is also provided.This publication has 136 references indexed in Scilit:
- CD38/CD31, the CCL3 and CCL4 Chemokines, and CD49d/Vascular Cell Adhesion Molecule-1 Are Interchained by Sequential Events Sustaining Chronic Lymphocytic Leukemia Cell SurvivalCancer Research, 2009
- Computational identification of CDR3 sequence archetypes among immunoglobulin sequences in chronic lymphocytic leukemiaLeukemia Research, 2009
- Molecular and clinical features of chronic lymphocytic leukaemia with stereotyped B cell receptors: results from an Italian multicentre studyBritish Journal of Haematology, 2009
- Adoptive T-cell immunotherapy of chronic lymphocytic leukaemiaBest Practice & Research Clinical Haematology, 2008
- MiR-15a and miR-16-1 cluster functions in human leukemiaProceedings of the National Academy of Sciences of the United States of America, 2008
- CD49d expression is an independent predictor of overall survival in patients with chronic lymphocytic leukaemia: a prognostic parameter with therapeutic potentialBritish Journal of Haematology, 2008
- Comprehensive genetic characterization of CLL: a study on 506 cases analysed with chromosome banding analysis, interphase FISH, IgVH status and immunophenotypingLeukemia, 2007
- Analysis of 11q22–q23 deletion target genes in B-cell chronic lymphocytic leukaemia: Evidence for a pathogenic role of NPAT, CUL5, and PPP2R1BEuropean Journal of Cancer, 2007
- Telomerase expression in B-cell chronic lymphocytic leukemia predicts survival and delineates subgroups of patients with the same igVH mutation status and different outcomeLeukemia, 2007
- Confounding B-cell defences: lessons from a staphylococcal superantigenNature Reviews Immunology, 2006