Obesity-induced hypertension in the dog.
- 1 June 1987
- journal article
- abstracts
- Published by Ovid Technologies (Wolters Kluwer Health) in Hypertension
- Vol. 9 (6_pt_2), III64-8
- https://doi.org/10.1161/01.hyp.9.6_pt_2.iii64
Abstract
To study the relationship between body weight and blood pressure, we have developed an animal model of obesity-induced hypertension. Nine adult mongrel dogs were chronically instrumented with aortic and vena caval catheters. After a 2-week control period, all dogs were made to gain weight by adding 2 lb/day of beef fat to their diet for 5 weeks. Blood pressure, heart rate, and body weight were measured daily before the addition of dietary fat, during the 5 weeks of the high fat diet, and for 6 weeks after the fat supplement was stopped. Plasma volume and cardiac output were measured prior to and after 5 weeks of the fat diet. During the 5-week high fat diet, the dogs' body weight increased from 22.2 +/- 2.1 to 27.4 +/- 3 kg (p less than 0.001); mean blood pressure increased from 90 +/- 5 to 112 +/- 6 mm Hg (p less than 0.01); and heart rate increased from 70 +/- 7 to 85 +/- 5 beats/min (p less than 0.05). Blood pressure, heart rate, and body weight returned to near control values after the fat diet was stopped. Over the 5-week fat diet, the dogs' plasma volume increased from 920 +/- 130 to 1059 +/- 195 ml (p less than 0.05); cardiac output increased from 2.5 +/- 0.4 to 3.1 +/- 0.3 L/min (p less than 0.05); and systemic vascular resistance increased from 35.3 +/- 8 to 38.9 +/- 9 mm Hg/L/min (p less than 0.1). Weight gain in the dogs was also associated with hyperinsulinemia and insulin resistance.(ABSTRACT TRUNCATED AT 250 WORDS)Keywords
This publication has 15 references indexed in Scilit:
- Insulin and blood pressure in obesity.Hypertension, 1985
- Importance of dietary salt in the hemodynamic adjustment to weight reduction in obese hypertensive men.Hypertension, 1984
- Disparate cardiovascular effects of obesity and arterial hypertensionAmerican Journal Of Medicine, 1983
- Mechanisms of Hypertension Associated with ObesityAnnals of Internal Medicine, 1983
- Reductions in plasma catecholamines and blood pressure during weight loss in obese subjectsActa Endocrinologica, 1983
- Role of the Sympathetic Nervous System in Blood Pressure Maintenance in ObesityJournal of Clinical Endocrinology & Metabolism, 1982
- Obesity and Essential HypertensionArchives of Internal Medicine, 1981
- Weight and blood pressure. Findings in hypertension screening of 1 million AmericansJAMA, 1978
- Hemodynamic role of extracellular fluid in hypertension.Circulation Research, 1976
- OBESITY AND HYPERTENSION: CLINICAL AND EXPERIMENTAL OBSERVATIONSAnnals of Internal Medicine, 1939