Long‐Term Prognosis of Patients with Biliary Atresia: A 25 Year Summary
- 1 February 2006
- journal article
- research article
- Published by Wiley in Journal of Pediatric Gastroenterology and Nutrition
- Vol. 42 (2), 190-195
- https://doi.org/10.1097/01.mpg.0000189339.92891.64
Abstract
Objective: The purpose of this study was to delineate the long-term prognosis of biliary atresia (BA) in Taiwan. Study Design: From 1976 to 2000, 185 children were diagnosed with BA, 22 underwent exploratory laparotomy without Kasai operation, and 163 underwent Kasai operation, of which 141 cases had long-term follow-up and formed the basis of this study. The outcome was analyzed. Results: Among the 141 BA children studied who underwent Kasai operation, 115 (81.6%) had recoloration of stools, and 86 (61.0%) became jaundice-free (bilirubin <20 μmol/L). The resolution of jaundice and the absence of repeated cholangitis contributed to better outcome. Five and 10 year survival rates with native liver were 35% and 31%, respectively. Liver transplantation was performed in 19 patients (all but 2 with a living-related donor), and 15 (79%) survived. Five and 10 year overall survival rates for BA patients were 41.9% and 40.2%, respectively. Conclusions: The study delineated the long-term outcome of BA in an Asian country other than Japan. Survival with native liver after a Kasai operation in Taiwan was similar to that in the American and European series. Limited donors for liver transplantation in the years of the study accounted for the poor overall prognosis of BA patients in this series.Keywords
This publication has 19 references indexed in Scilit:
- Outcome in adulthood of biliary atresia: A study of 63 patients who survived for over 20 years with their native liverHepatology, 2005
- Long-term Survival Following Kasai Portoenterostomy: Is Chronic Liver Disease Inevitable?Journal of Pediatric Gastroenterology and Nutrition, 2003
- Epidemiology of biliary atresia in France: a national study 1986–96Journal of Hepatology, 1999
- Prognosis of biliary atresia in the era of liver transplantation: French national study from 1986 to 1996Hepatology, 1999
- A Multivariable Risk Factor Analysis of the Portoenterostomy (Kasai) Procedure for Biliary AtresiaAnnals of Surgery, 1997
- Current status of 21 patients who have survived more than 20 years since undergoing surgery for biliary atresiaJournal of Pediatric Surgery, 1996
- Differential Diagnosis of Extrahepatic Biliary Atresia from Neonatal HepatitisJournal of Pediatric Gastroenterology and Nutrition, 1994
- Long-term follow-up after surgery for patients with biliary atresiaJournal of Pediatric Surgery, 1990
- Optimal therapy for patients with biliary atresia: Portoenterostomy (“Kasai” procedures) versus primary transplantationJournal of Pediatric Surgery, 1990
- Bacterial cholangitis after surgery forbiliary atresiaThe Journal of Pediatrics, 1987