Ultrastructural evidence suggesting an immunomodulatory activity of oral retinoid.
- 1 January 1981
- journal article
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 104 (1), 37-46
- https://doi.org/10.1111/j.1365-2133.1981.tb01709.x
Abstract
The effects of the aromatic retinoid RO 10-9359 on the fine structure of psoriatic dermis were investigated by electron microscopy in five patients after 1, 2, and 3 weeks of treatment (I mg/kg/day). Our findings show that aromatic retinoid, additionally to its epidermal effects, exerts a distinct influence on dermal components in psoriasis. Ultrastructural evidence is provided suggesting that this drug stimulates lymphocytes and monocytes, promoting their differentiation into Sézary-like lymphocytic cells, activated macrophages and dermal Langerhans cells. The appearance of these immunocompetent cell lines may modulate the cell-mediated immune response in psoriasis, obviously reflecting a pharmacological action of the drug additional to its definite influence on epidermal keratinization.Keywords
This publication has 17 references indexed in Scilit:
- Retinoic acid in psoriasis: its value for topical therapy with and without corticosteroidsBritish Journal of Dermatology, 2006
- Epidermal Langerhans cells are derived from cells originating in bone marrowNature, 1979
- Mouse epidermal Ia molecules have a bone marrow originNature, 1979
- Laboratory Investigations in Patients with Generalized Psoriasis under Oral Retinoid TreatmentDermatology, 1979
- Inflammatory and Immune Cell Function in Psoriasis—A Subtle Disorder I. In Vivo and In Vitro SurveyJournal of Investigative Dermatology, 1978
- Subpopulations of human T lymphocytesCellular Immunology, 1978
- Defective Function of T Lymphocytes in PsoriasisJournal of Investigative Dermatology, 1978
- Tissue Changes in Psoriatic Plaques after Oral Administration of RetinoidDermatology, 1978
- A fine structural study on the therapeutic effect on an aromatic retinoid on chemically-induced skin papillomas of the mouseEuropean Journal of Cancer (1965), 1977
- Nonspecificity of characteristic cells in mycosis fungoidesArchives of Dermatology, 1971