Distortion-correctedT2weighted MRI: a novel approach to prostate radiotherapy planning
- 1 November 2007
- journal article
- research article
- Published by Oxford University Press (OUP) in The British Journal of Radiology
- Vol. 80 (959), 926-933
- https://doi.org/10.1259/bjr/51363812
Abstract
The purpose of this study was to evaluate distortion-corrected MRI as a radiotherapy planning tool for prostate cancer and the resultant implications for dose sparing of organs at risk. 11 men who were to be treated with radical conformal radiotherapy for localized prostate cancer had an MRI scan under radiotherapy planning conditions, which was corrected for geometric distortion. Radiotherapy plans were created for planning target volumes derived from the MRI- and CT-defined prostate. Dose volume histograms were produced for the rectum, bladder and penile bulb. The mean volume of the prostate as defined on CT and MRI was 41 cm3 and 36 cm3, respectively (p = 0.009). The predicted percentage of the rectum treated to dose levels of 45–65 Gy was significantly lower for plans delineating the prostate with MRI than for those with CT. The rectal-sparing effect was confined to the lowermost 4 cm of the rectum (anal canal). There were no differences between the predicted doses to bladder or penile bulb (as defined using MRI) between plans. In conclusion, prostate radiotherapy planning based on distortion-corrected MRI is feasible and results in a smaller target volume than does CT. This leads to a lower predicted proportion of the rectum, in particular the lower rectum (anal canal), treated to a given dose than with CT.This publication has 37 references indexed in Scilit:
- A complete distortion correction for MR images: II. Rectification of static-field inhomogeneities by similarity-based profile mappingPhysics in Medicine & Biology, 2005
- A complete distortion correction for MR images: I. Gradient warp correctionPhysics in Medicine & Biology, 2005
- Gastrointestinal toxicity and its relation to dose distributions in the anorectal region of prostate cancer patients treated with radiotherapyInternational Journal of Radiation Oncology*Biology*Physics, 2005
- Dose–volume histograms associated to long-term colorectal functions in patients receiving pelvic radiotherapyRadiotherapy and Oncology, 2005
- Impact of volume and location of irradiated rectum wall on rectal blood loss after radiotherapy of prostate cancerInternational Journal of Radiation Oncology*Biology*Physics, 2004
- Radiotherapy treatment planning of prostate cancer using magnetic resonance imaging aloneRadiotherapy and Oncology, 2003
- Anorectal function after modern conformal radiation therapy for prostate cancer: a pilot studyTechniques in Coloproctology, 2002
- CT–MRI image fusion for delineation of volumes in three-dimensional conformal radiation therapy in the treatment of localized prostate cancerThe British Journal of Radiology, 2002
- Comparison of MRI with CT for the radiotherapy planning of prostate cancer: a feasibility study.The British Journal of Radiology, 1999
- Prostate volumes defined by magnetic resonance imaging and computerized tomographic scans for three-dimensional conformal radiotherapyInternational Journal of Radiation Oncology*Biology*Physics, 1996