Phenotypic switching in newly emerged multidrug-resistant pathogen Candida auris
Open Access
- 16 October 2018
- journal article
- research article
- Published by Oxford University Press (OUP) in Medical Mycology
- Vol. 57 (5), 636-638
- https://doi.org/10.1093/mmy/myy100
Abstract
Candida auris is an emerging, multidrug-resistant yeast that can spread rapidly in healthcare settings. Phenotypic switching has been observed in other Candida species and can potentially interfere with correct identification. The aim of this study is to address misidentification of C. auris by describing alternate phenotypes after broth enrichment and subculturing on CHROMagar Candida. Each isolate displayed different frequencies of phenotypic switching, suggesting a strain to strain variability. Increased knowledge of the multiple phenotypes of C. auris increases the chance of isolating and identifying C. auris by reducing the risk of discarding false negative alternate colony morphologies.Keywords
This publication has 14 references indexed in Scilit:
- Survival, Persistence, and Isolation of the Emerging Multidrug-Resistant Pathogenic Yeast Candida auris on a Plastic Health Care SurfaceJournal of Clinical Microbiology, 2017
- Approach to the Investigation and Management of Patients With Candida auris, an Emerging Multidrug-Resistant YeastClinical Infectious Diseases, 2017
- Simultaneous Emergence of Multidrug-ResistantCandida aurison 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological AnalysesClinical Infectious Diseases, 2016
- Passage through the mammalian gut triggers a phenotypic switch that promotes Candida albicans commensalismNature Genetics, 2013
- Stress-Induced Phenotypic Switching inCandida albicansMolecular Biology of the Cell, 2009
- Candida aurissp. nov., a novel ascomycetous yeast isolated from the external ear canal of an inpatient in a Japanese hospitalMicrobiology and Immunology, 2009
- Bistable expression of WOR1 , a master regulator of white–opaque switching in Candida albicansProceedings of the National Academy of Sciences of the United States of America, 2006
- Epigenetic properties of white–opaque switching in Candida albicans are based on a self-sustaining transcriptional feedback loopProceedings of the National Academy of Sciences of the United States of America, 2006
- MATING IN CANDIDA ALBICANS AND THE SEARCH FOR A SEXUAL CYCLEAnnual Review of Microbiology, 2005
- Gapped BLAST and PSI-BLAST: a new generation of protein database search programsNucleic Acids Research, 1997