Can .GAMMA.-Glutamyltransferase be an Additional Marker of Arterial Stiffness?
- 1 January 2007
- journal article
- clinical trial
- Published by Japanese Circulation Society in Circulation Journal
- Vol. 71 (11), 1715-1720
- https://doi.org/10.1253/circj.71.1715
Abstract
It has been recently suggested that gamma-glutamyltransferase (GGT) is independently associated with cardiovascular mortality and atherosclerosis, so the present study evaluated whether GGT is an additional marker of arterial stiffness, independent of other risk factors, in screening cohorts. The 1,387 individuals (741 men, 646 women) who underwent brachial - ankle pulse wave velocity (baPWV) measurement had their serum levels of GGT, creatinine, uric acid, C-reactive protein, lipids, fasting glucose and insulin, and their hepatitis profiles checked. There were statistically significant increments of baPWV according to quartile of GGT, which was statistically significant in women, but not in men. In logistic regression analysis, age, diabetes mellitus, GGT, heart rate, history of hypertension, triglyceride, and systolic blood pressure were significant variables that influenced increased pulse wave velocity (PWV). After age-and blood pressure-adjustment, GGT, homeostatic model assessment-insulin resistance, heart rate, history of hypertension, and metabolic syndrome were significant variables in men, and in women metabolic syndrome and history of hypertension were significant contributors to increased PWV. The present study results suggest that serum GGT may be an additional marker of arterial stiffness, especially in men, though the relationship with arterial stiffness was very weak. Further studies are needed to elucidate the mechanism of GGT's contribution to arteriosclerosis and to confirm the current results.Keywords
This publication has 19 references indexed in Scilit:
- Serum γ-glutamyltransferase is a predictor of incident coronary events in apparently healthy men from the general populationAtherosclerosis, 2006
- Increased Pulse Wave Velocity Is Associated With Low Creatinine Clearance and Proteinuria in a Screened CohortAmerican Journal of Kidney Diseases, 2006
- γ-Glutamyltransferase as a Risk Factor for Cardiovascular Disease MortalityCirculation, 2005
- Association between serum C-reactive protein levels and pulse wave velocity: a population-based cross-sectional study in a general populationAtherosclerosis, 2005
- Reproducibility of Arterial Stiffness Indices (Pulse Wave Velocity and Augmentation Index) Simultaneously Assessed by Automated Pulse Wave Analysis and Their Associated Risk Factors in Essential Hypertensive PatientsHypertension Research, 2004
- Validity, Reproducibility, and Clinical Significance of Noninvasive Brachial-Ankle Pulse Wave Velocity Measurement.Hypertension Research, 2002
- Arterial compliance to stratify cardiovascular risk: more precision in therapeutic decision makingAmerican Journal of Hypertension, 2001
- Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)Jama-Journal Of The American Medical Association, 2001
- Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in manDiabetologia, 1985
- Induction of hepatic microsomal gamma-glutamyltransferase activity following chronic alcohol consumptionBiochemical and Biophysical Research Communications, 1977