InvasiveHaemophilus influenzaeDisease, Europe, 1996–2006
Open Access
- 1 March 2010
- journal article
- research article
- Published by Centers for Disease Control and Prevention (CDC) in Emerging Infectious Diseases
- Vol. 16 (3), 455-463
- https://doi.org/10.3201/eid1603.090290
Abstract
An international collaboration was established in 1996 to monitor the impact of routine Haemophilus influenzae type b (Hib) vaccination on invasive H. influenzae disease; 14 countries routinely serotype all clinical isolates. Of the 10,081 invasive H. influenzae infections reported during 1996–2006, 4,466 (44%, incidence 0.28 infections/100,000 population) were due to noncapsulated H. influenzae (ncHi); 2,836 (28%, 0.15/100,000), to Hib; and 690 (7%, 0.036/100,000), to non–b encapsulated H. influenzae. Invasive ncHi infections occurred in older persons more often than Hib (median age 58 years vs. 5 years, p<0.0001) and were associated with higher case-fatality ratios (12% vs. 4%, p<0.0001), particularly in infants (17% vs. 3%, p<0.0001). Among non-b encapsulated H. influenzae, types f (72%) and e (21%) were responsible for almost all cases; the overall case-fatality rate was 9%. Thus, the incidence of invasive non–type b H. influenzae is now higher than that of Hib and is associated with higher case fatality.Keywords
This publication has 39 references indexed in Scilit:
- No evidence for Haemophilus influenzae serotype replacement in Europe after introduction of the Hib conjugate vaccineThe Lancet Infectious Diseases, 2008
- Epidemiology ofHaemophilus influenzaeSerotype a, North American Arctic, 2000–2005Emerging Infectious Diseases, 2008
- Capsule switching and capsule replacement in vaccine-preventable bacterial diseasesThe Lancet Infectious Diseases, 2007
- Nontypeable Haemophilus influenzae Meningitis in Children: Phenotypic and Genotypic Characterization of IsolatesThe Pediatric Infectious Disease Journal, 2007
- Haemophilus influenzae meningitis 5 years after introduction of the Haemophilus influenzae type b conjugate vaccine in BrazilVaccine, 2007
- The Changing Epidemiology of Invasive Haemophilus influenzae Disease, Especially in Persons >=65 Years OldClinical Infectious Diseases, 2007
- Clonal relationship of recent invasive Haemophilus influenzae serotype f isolates from Denmark and the United StatesJournal of Medical Microbiology, 2004
- Prevention ofHaemophilus influenzaeType b (Hib) Meningitis and Emergence of Serotype Replacement with Type a Strains after Introduction of Hib Immunization in BrazilThe Journal of Infectious Diseases, 2003
- Limited Genetic Diversity of Recent Invasive Isolates of Non-Serotype b Encapsulated Haemophilus influenzaeJournal of Clinical Microbiology, 2002
- Epidemiology of invasiveHaemophilus influenzaeinfections in England and Wales in the pre-vaccination era (1990–2)Epidemiology and Infection, 1995