Mechanisms of Respiratory Syncytial Virus Modulation of Airway Immune Responses
Open Access
- 13 June 2012
- journal article
- review article
- Published by Springer Science and Business Media LLC in Current Allergy and Asthma Reports
- Vol. 12 (5), 380-387
- https://doi.org/10.1007/s11882-012-0278-z
Abstract
Respiratory syncytial virus (RSV) most often causes severe respiratory disease in the very young and the elderly. Acute disease can also cause exacerbations of asthma in any age group. Recent findings provide insight into how the innate and adaptive immune systems respond to RSV infection and provide preliminary evidence that these effects vary significantly by RSV strain and host. Components of cell signaling pathways that induce inflammatory cytokine expression during the innate immune response and alter epithelial cell polarity through activating transcription factors, namely NF-κB, are now more clearly understood. New studies also reveal how RSV infection skews T helper (Th) cell differentiation away from the cell-mediated Th1 subset and towards the Th2 subset. There are also new data supporting preferential Th17 differentiation during RSV infection. In addition, effective immune system regulation of IL-10 expression and T regulatory cell (Treg) airway accumulation are essential for effective RSV clearance.Keywords
This publication has 54 references indexed in Scilit:
- Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infectionMucosal Immunology, 2012
- Local interleukin-10 production during respiratory syncytial virus bronchiolitis is associated with post-bronchiolitis wheezeRespiratory Research, 2011
- Treatment of allergic asthma: Modulation of Th2 cells and their responsesRespiratory Research, 2011
- TAK1 regulates NF-ΚB and AP-1 activation in airway epithelial cells following RSV infectionVirology, 2011
- A nuclear factor-κB signaling pathway via protein kinase C δ regulates replication of respiratory syncytial virus in polarized normal human nasal epithelial cellsMolecular Biology of the Cell, 2011
- Differential Pathogenesis of Respiratory Syncytial Virus Clinical Isolates in BALB/c MiceJournal of Virology, 2011
- IL-17–Induced Pulmonary Pathogenesis during Respiratory Viral Infection and Exacerbation of Allergic DiseaseThe American Journal of Pathology, 2011
- IKKε modulates RSV-induced NF-κB-dependent gene transcriptionVirology, 2010
- Toll-Like Receptor 4-Mediated Activation of p38 Mitogen-Activated Protein Kinase Is a Determinant of Respiratory Virus Entry and TropismJournal of Virology, 2010
- Respiratory Syncytial Virus Activates Innate Immunity through Toll-Like Receptor 2Journal of Virology, 2009