Chrysin Protects Epidermal Keratinocytes from UVA- and UVB-Induced Damage
- 6 July 2011
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Agricultural and Food Chemistry
- Vol. 59 (15), 8391-8400
- https://doi.org/10.1021/jf200931t
Abstract
Chrysin (5,7-dihydroxyflavone), a natural flavonoid occurring in various plants and foods such as propolis and honey, reportedly opposes inflammation and carcinogenesis, but has rarely been applied in skin care. This study, therefore, aimed to explore the roles of chrysin in protection against UV-induced damage in HaCaT keratinocytes. Results showed that chrysin can attenuate apoptosis, reactive oxygen species (ROS) production, and cyclooxygenase 2 (COX-2) expression induced by UVB and UVA. Chrysin predominantly reversed the down-regulation of aquaporin 3 (AQP-3) by UVB. It predominantly reversed JNK activation and also mildly inhibited p38 activation triggered by UVA and UVB. Animal studies revealed that chrysin’s topical application demonstrated efficient percutaneous absorption and no skin irritation. Overall, results demonstrated significant benefits of chrysin on the protection of keratinocytes against UVA- and UVB-induced injuries and suggested its potential use in skin photoprotection.Keywords
This publication has 35 references indexed in Scilit:
- Roles of Aquaporin-3 in the EpidermisJournal of Investigative Dermatology, 2008
- Cyclo‐oxygenase‐2 Plays a Critical Role in UV‐induced Skin Carcinogenesis†Photochemistry and Photobiology, 2008
- All‐trans retinoic acid attenuates ultraviolet radiation‐induced down‐regulation of aquaporin‐3 and water permeability in human keratinocytesJournal of Cellular Physiology, 2007
- Photoageing: mechanism, prevention and therapyBritish Journal of Dermatology, 2007
- Apigenin Prevents UVB-Induced Cyclooxygenase 2 Expression: Coupled mRNA Stabilization and Translational InhibitionMolecular and Cellular Biology, 2007
- Oxidative Stress in the Pathogenesis of Skin DiseaseJournal of Investigative Dermatology, 2006
- Cyclooxygenase-2 Overexpression in Human Basal Cell Carcinoma Cell Line Increases Antiapoptosis, Angiogenesis, and TumorigenesisJournal of Investigative Dermatology, 2006
- Curcumin inhibits the expression of COX-2 in UVB-irradiated human keratinocytes (HaCaT) by inhibiting activation of AP-1: p38 MAP kinase and JNK as potential upstream targetsExperimental & Molecular Medicine, 2005
- Photochemoprevention of ultraviolet B signaling and photocarcinogenesisMutation Research, 2005
- Cyclooxygenases in the skin: pharmacological and toxicological implicationsToxicology and Applied Pharmacology, 2003