The phosphatase system in Saccharomyces cerevisiae.
- 1 January 1997
- journal article
- review article
- Published by Genetics Society of Japan in Genes & Genetic Systems
- Vol. 72 (6), 323-334
- https://doi.org/10.1266/ggs.72.323
Abstract
The yeast Saccharomyces cerevisiae has at least six species of acid and alkaline phosphatases with different cellular localizations, as well as inorganic phosphate (Pi) transporters. Most of the genes encoding these enzymes are coordinately repressed and derepressed depending on the Pi concentration in the growth medium. The Pi signals are conveyed to these genes through a regulatory circuit consisting of a set of positive and negative regulatory proteins. This phosphatase system is interested as one of the best systems for studying gene regulation in S. cerevisiae due to the simplicity of phenotype determination in genetic analysis. With this methodological advantage, considerable amounts of genetic and molecular evidence in phosphatase regulation have been accumulated in the past twenty-five years. This article summarizes the current progress of research into this subject.Keywords
This publication has 92 references indexed in Scilit:
- Transcriptional activation by recruitmentNature, 1997
- A putative new membrane protein, Pho86p, in the inorganic phosphate uptake system of Saccharomyces cerevisiaeGene, 1996
- Interaction ofMolecular Genetics and Genomics, 1996
- A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4Nature, 1993
- Transcriptional activation of CLN1, CLN2, and a putative new G1 cyclin (HCS26) by SWI4, a positive regulator of G1-specific transcriptionCell, 1991
- Yeast fructose‐2,6‐bisphosphate 6‐phosphatase is encoded by PHO8, the gene for nonspecific repressible alkaline phosphataseEuropean Journal of Biochemistry, 1991
- High affinity of acid phosphatase encoded by PHO3 gene in Saccharomyces cerevisiae for thiamin phosphatesBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1990
- The yeast regulatory gene PHO2 encodes a homeo boxCell, 1988
- Multiple Global Regulators Control HIS4 transcription in YeastScience, 1987
- A gene controlling the synthesis of non specific alkaline phosphatase in Saccharomyces cerevisiaeBiochimica et Biophysica Acta (BBA) - General Subjects, 1976