Selection of Early-Occurring Mutations Dictates Hormone-Independent Progressionin Mouse Mammary TumorLines
Open Access
- 1 November 2006
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 80 (22), 11409-11415
- https://doi.org/10.1128/jvi.00234-06
Abstract
Mice harboring three mouse mammary tumor virus (MMTV) variants develop pregnancy-dependent (PD) tumors that progress to pregnancy-independent (PI) behavior through successive passages. Herein, we identified 10 predominant insertions in PI transplants from 8 independent tumor lines. These mutations were also detected in small cell populations in the early PD passages. In addition, we identified a new viral insertion upstream of the gene Rspo3 , which is overexpressed in three of the eight independent tumor lines and codes for a protein very similar to the recently described protein encoded by Int7 . This study suggests that during progression towards hormone independence, clonal expansion of cells with specific mutations might be more relevant than the occurrence of new MMTV insertions.Keywords
This publication has 25 references indexed in Scilit:
- R-Spondin Proteins: A Novel Link to β-catenin ActivationCell Cycle, 2005
- A New Common Integration Site, Int7, for the Mouse Mammary Tumor Virus in Mouse Mammary Tumors Identifies a Gene Whose Product Has Furin-Like and Thrombospondin-Like SequencesJournal of Virology, 2005
- Progression of Pregnancy-Dependent Mouse Mammary Tumors after Long Dormancy Periods. Involvement of Wnt Pathway ActivationCancer Research, 2004
- EBAG9/RCAS1 expression and its prognostic significance in prostatic cancerInternational Journal of Cancer, 2003
- Leukemia Inhibitory Factor Induces Apoptosis of the Mammary Epithelial Cells and Participates in Mouse Mammary Gland InvolutionExperimental Cell Research, 2003
- Impairment of mammary lobular development induced by expression of TGF?1 under the control of WAP promoter does not suppress tumorigenesis in MMTV-infected transgenic miceInternational Journal of Cancer, 2001
- Identification and Characterization of the Human Homologue (RAI2) of a Mouse Retinoic Acid-Induced Gene in Xp22Genomics, 1999
- Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit.The Journal of cell biology, 1995
- Mouse mammary‐tumor virus activates Fgf‐3/Int‐2 less frequently in tumors from virgin than from parous miceInternational Journal of Cancer, 1993
- Activation of cellular gene by mouse mammary tumour virus may occur early in mammary tumour developmentNature, 1984