Prurigo nodularis: A review
- 30 September 2005
- journal article
- review article
- Published by Wiley in Australasian Journal of Dermatology
- Vol. 46 (4), 211-220
- https://doi.org/10.1111/j.1440-0960.2005.00187.x
Abstract
Prurigo nodularis is a chronic condition characterized by a papulonodular pruriginous eruption of unknown aetiology. This condition is a difficult disease to treat and causes frustration to both the patient and the treating doctor. A variety of systemic conditions have been reported to be associated with prurigo nodularis. The mechanism by which these disorders may trigger prurigo nodularis is unknown. Nerve growth factor has been implicated in the pathogenesis of prurigo nodularis. Calcitonin gene-related peptide and substance P immunoreactive nerves are markedly increased in prurigo nodularis when compared with normal skin. These neuropeptides may mediate the cutaneous neurogenic inflammation and pruritus in prurigo nodularis. Topical or intralesional glucocorticoids are the treatment of choice. Other topical treatments such as topical vitamin D3, and topical capsaicin have also been reported to be effective. Oral treatments such as cyclosporin and thalidomide have been shown to improve both appearance of the skin and pruritus. We review the clinical features, associations, pathology, pathogenesis and treatment of prurigo nodularis.Keywords
This publication has 95 references indexed in Scilit:
- Prurigo nodularis in an HIV positive patientJournal of the American Academy of Dermatology, 2004
- Pemphigoid nodularis associated with autoantibodies to the NC16A domain of BP180 and a hyperproliferative integrin profileJournal of the American Academy of Dermatology, 2001
- Mycobacteria in prurigo nodularis: The cause or aconsequence?Journal of the American Academy of Dermatology, 1996
- Evidence for nerve growth factor-mediated paracrine effects in human epidermis.The Journal of cell biology, 1991
- Anetodermic prurigo nodularis (with Pautrier's neuroma) responsive to arotinoid acidJournal of the American Academy of Dermatology, 1991
- Topical capsaicin treatment of chronic postherpetic neuralgiaJournal of the American Academy of Dermatology, 1989
- NaltrexoneDrugs, 1988
- Effects of topically applied capsaicin on moderate and severe psoriasis vulgarisJournal of the American Academy of Dermatology, 1986
- Histamine release and vascular changes induced by neuropeptidesInflammation Research, 1983
- Butorphanol-induced pruritus antagonized by naloxoneJournal of the American Academy of Dermatology, 1981