Extinction, renewal, and spontaneous recovery of a spatial preference in the water maze.
- 1 January 2003
- journal article
- Published by American Psychological Association (APA) in Behavioral Neuroscience
- Vol. 117 (5), 1017-1028
- https://doi.org/10.1037/0735-7044.117.5.1017
Abstract
Four experiments with C57BL/6 mice investigated extinction of a spatial preference in the Morris water maze. In Experiment 1, a spatial preference was extinguished by exposing mice to the water maze in the absence of a platform but in the presence of the distal spatial cues. In Experiment 2, extinction occurred when the platform was removed from the pool, when it was presented in random locations, or when it was presented consistently in the opposite location. Contextual renewal (Experiment 3) and spontaneous recovery (Experiment 4) of spatial preferences argue against an interpretation of extinction in terms of unlearning and instead suggest that extinction in the water maze, like extinction in Pavlovian conditioning, suppresses the original association. Implications of these findings for theories of spatial learning and hippocampal function are discussed.Keywords
This publication has 43 references indexed in Scilit:
- Spatial Processing in the Brain: The Activity of Hippocampal Place CellsAnnual Review of Neuroscience, 2001
- Overshadowing in the spatial domainLearning & Behavior, 1999
- Do hippocampal pyramidal cells signal non-spatial as well as spatial information?Hippocampus, 1999
- Hippocampus as a memory map: Synaptic plasticity and memory encoding by hippocampal neuronsHippocampus, 1999
- Spontaneous recovery after extinction of a conditioned taste aversionLearning & Behavior, 1996
- Inhibitory associations between S and R in extinctionLearning & Behavior, 1993
- Context, time, and memory retrieval in the interference paradigms of Pavlovian learning.Psychological Bulletin, 1993
- A layered network model of associative learning: Learning to learn and configuration.Psychological Review, 1988
- Place navigation impaired in rats with hippocampal lesionsNature, 1982
- The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving ratBrain Research, 1971