Chronic Stress Facilitates the Development of Deep Venous Thrombosis
Open Access
- 1 January 2015
- journal article
- research article
- Published by Hindawi Limited in Oxidative Medicine and Cellular Longevity
- Vol. 2015, 1-8
- https://doi.org/10.1155/2015/384535
Abstract
The increasing pressure of modern social life intensifies the impact of stress on the development of cardiovascular diseases, which include deep venous thrombosis (DVT). Renal sympathetic denervation has been applied as one of the clinical approaches for the treatment of drug-resistant hypertension. In addition, the close relationship between oxidative stress and cardiovascular diseases has been well documented. The present study is designed to explore the mechanism by which the renal sympathetic nerve system and the oxidative stress affect the blood coagulation system in the development of DVT. Chronic foot shock model in rats was applied to mimic a state of physiological stress similar to humans. Our results showed that chronic foot shock procedure could promote DVT which may be through the activation of platelets aggregation. The aggravation of DVT and activation of platelets were alleviated by renal sympathetic denervation or antioxidant (Tempol) treatment. Concurrently, the denervation treatment could also reduce the levels of circulating oxidation factors in rats. These results demonstrate that both the renal sympathetic nerve system and the oxidative stress contribute to the development of DVT in response to chronic stress, which may provide novel strategy for treatment of clinic DVT patients.Keywords
Funding Information
- National Natural Science Foundation of China (81270316, 814170563, Q413400111)
This publication has 39 references indexed in Scilit:
- Sympatho-renal axis in chronic diseaseClinical Research in Cardiology, 2011
- Microvascular Responses to Cardiovascular Risk FactorsMicrocirculation, 2010
- EFFECTS OF MELATONIN ON BLOOD PRESSURE IN STRESS-INDUCED HYPERTENSION IN RATSClinical and Experimental Pharmacology and Physiology, 2008
- Role of AT1 receptor in isoproterenol-induced cardiac hypertrophy and oxidative stress in miceJournal of Molecular and Cellular Cardiology, 2007
- Nebivolol Inhibits Superoxide Formation by NADPH Oxidase and Endothelial Dysfunction in Angiotensin II–Treated RatsHypertension, 2006
- Effects of Captopril on the Renin Angiotensin System, Oxidative Stress, and Endothelin in Normal and Hypertensive RatsHypertension, 2005
- Determinants of Platelet Activation in Human Essential HypertensionHypertension, 2004
- Emotional Stress and Characteristics of Brain Noradrenaline Release in the Rat.Industrial Health, 1999
- Mental stress increases sympathetic nerve activity during sustained baroreceptor stimulation in humans.Hypertension, 1991
- Sympathetic modulation of renal hemodynamics, renin release and sodium excretionJournal of Molecular Medicine, 1989